The proteome of human saliva

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Human saliva holds tremendous potential for transforming disease and health diagnostics given its richness of molecular information and non-invasive collection. Enumerating its molecular constituents is an important first step towards reaching this potential. Among the molecules in saliva, proteins and peptides arguably have the most value: they can directly indicate biochemical functions linked to a health condition/disease state, and they are attractive targets for biomarker assay development. However, cataloging and defining the human salivary proteome is challenging given the dynamic, chemically heterogeneous and complex nature of the system. In addition, the overall human saliva proteome is composed of several "sub-proteomes" which include: intact full length proteins, proteins carrying post-translational modifications (PTMs), low molecular weight peptides, and the metaproteome, derived from protein products from nonhuman organisms (e.g. microbes) present in the oral cavity. Presented here will be a summary of communal efforts to meet the challenge of characterizing the multifaceted saliva proteome, focusing on the use of mass spectrometry as the proteomic technology of choice. Implications of these efforts to characterize the salivary proteome in the context of disease diagnostics will also be discussed.

Original languageEnglish (US)
Title of host publicationSensing Technologies for Global Health, Military Medicine, and Environmental Monitoring III
Volume8723
DOIs
StatePublished - Aug 12 2013
EventSensing Technologies for Global Health, Military Medicine, and Environmental Monitoring III - Baltimore, MD, United States
Duration: Apr 29 2013May 1 2013

Other

OtherSensing Technologies for Global Health, Military Medicine, and Environmental Monitoring III
CountryUnited States
CityBaltimore, MD
Period4/29/135/1/13

Fingerprint

proteome
saliva
Proteome
Proteins
Protein
proteins
Peptides
Diagnostics
Health
health
peptides
Proteomics
Biomarkers
Mass Spectrometry
biomarkers
microorganisms
low molecular weights
Cavity
organisms
Molecules

Keywords

  • Bioinformatics
  • Mass spectrometry
  • Metaproteomics
  • Peptidomics
  • Post-translational modifications
  • Proteomics
  • Tandem mass spectrometry
  • Whole saliva

Cite this

Griffin, T. J. (2013). The proteome of human saliva. In Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring III (Vol. 8723). [87230A] https://doi.org/10.1117/12.2020012

The proteome of human saliva. / Griffin, Timothy J.

Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring III. Vol. 8723 2013. 87230A.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Griffin, TJ 2013, The proteome of human saliva. in Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring III. vol. 8723, 87230A, Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring III, Baltimore, MD, United States, 4/29/13. https://doi.org/10.1117/12.2020012
Griffin TJ. The proteome of human saliva. In Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring III. Vol. 8723. 2013. 87230A https://doi.org/10.1117/12.2020012
Griffin, Timothy J. / The proteome of human saliva. Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring III. Vol. 8723 2013.
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