The proteome of human saliva

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Human saliva holds tremendous potential for transforming disease and health diagnostics given its richness of molecular information and non-invasive collection. Enumerating its molecular constituents is an important first step towards reaching this potential. Among the molecules in saliva, proteins and peptides arguably have the most value: they can directly indicate biochemical functions linked to a health condition/disease state, and they are attractive targets for biomarker assay development. However, cataloging and defining the human salivary proteome is challenging given the dynamic, chemically heterogeneous and complex nature of the system. In addition, the overall human saliva proteome is composed of several "sub-proteomes" which include: intact full length proteins, proteins carrying post-translational modifications (PTMs), low molecular weight peptides, and the metaproteome, derived from protein products from nonhuman organisms (e.g. microbes) present in the oral cavity. Presented here will be a summary of communal efforts to meet the challenge of characterizing the multifaceted saliva proteome, focusing on the use of mass spectrometry as the proteomic technology of choice. Implications of these efforts to characterize the salivary proteome in the context of disease diagnostics will also be discussed.

Original languageEnglish (US)
Title of host publicationSensing Technologies for Global Health, Military Medicine, and Environmental Monitoring III
DOIs
StatePublished - Aug 12 2013
EventSensing Technologies for Global Health, Military Medicine, and Environmental Monitoring III - Baltimore, MD, United States
Duration: Apr 29 2013May 1 2013

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume8723
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

ConferenceSensing Technologies for Global Health, Military Medicine, and Environmental Monitoring III
CountryUnited States
CityBaltimore, MD
Period4/29/135/1/13

Keywords

  • Bioinformatics
  • Mass spectrometry
  • Metaproteomics
  • Peptidomics
  • Post-translational modifications
  • Proteomics
  • Tandem mass spectrometry
  • Whole saliva

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  • Cite this

    Griffin, T. J. (2013). The proteome of human saliva. In Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring III [87230A] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 8723). https://doi.org/10.1117/12.2020012