The promise of organ and tissue preservation to transform medicine

Sebastian Giwa, Jedediah K. Lewis, Luis Alvarez, Robert Langer, Alvin E. Roth, George M. Church, James F. Markmann, David H. Sachs, Anil Chandraker, Jason A. Wertheim, Martine Rothblatt, Edward S. Boyden, Elling Eidbo, W. P.Andrew Lee, Bohdan Pomahac, Gerald Brandacher, David M. Weinstock, Gloria Elliott, David Nelson, Jason P. Acker & 22 others Korkut Uygun, Boris Schmalz, Brad P. Weegman, Alessandro Tocchio, Greg M. Fahy, Kenneth B. Storey, Boris Rubinsky, John Bischof, Janet A.W. Elliott, Teresa K. Woodruff, G. John Morris, Utkan Demirci, Kelvin G.M. Brockbank, Erik J. Woods, Robert N. Ben, John G. Baust, Dayong Gao, Barry Fuller, Yoed Rabin, David C. Kravitz, Michael J. Taylor, Mehmet Toner

Research output: Contribution to journalReview article

69 Citations (Scopus)

Abstract

The ability to replace organs and tissues on demand could save or improve millions of lives each year globally and create public health benefits on par with curing cancer. Unmet needs for organ and tissue preservation place enormous logistical limitations on transplantation, regenerative medicine, drug discovery, and a variety of rapidly advancing areas spanning biomedicine. A growing coalition of researchers, clinicians, advocacy organizations, academic institutions, and other stakeholders has assembled to address the unmet need for preservation advances, outlining remaining challenges and identifying areas of underinvestment and untapped opportunities. Meanwhile, recent discoveries provide proofs of principle for breakthroughs in a family of research areas surrounding biopreservation. These developments indicate that a new paradigm, integrating multiple existing preservation approaches and new technologies that have flourished in the past 10 years, could transform preservation research. Capitalizing on these opportunities will require engagement across many research areas and stakeholder groups. A coordinated effort is needed to expedite preservation advances that can transform several areas of medicine and medical science.

Original languageEnglish (US)
Pages (from-to)530-542
Number of pages13
JournalNature biotechnology
Volume35
Issue number6
DOIs
StatePublished - Jun 7 2017

Fingerprint

Tissue Preservation
Organ Preservation
Medicine
Tissue
Aptitude
Regenerative Medicine
Insurance Benefits
Drug Discovery
Research
Public Health
Transplantation
Research Personnel
Organizations
Public health
Technology
Curing
Neoplasms

Cite this

Giwa, S., Lewis, J. K., Alvarez, L., Langer, R., Roth, A. E., Church, G. M., ... Toner, M. (2017). The promise of organ and tissue preservation to transform medicine. Nature biotechnology, 35(6), 530-542. https://doi.org/10.1038/nbt.3889

The promise of organ and tissue preservation to transform medicine. / Giwa, Sebastian; Lewis, Jedediah K.; Alvarez, Luis; Langer, Robert; Roth, Alvin E.; Church, George M.; Markmann, James F.; Sachs, David H.; Chandraker, Anil; Wertheim, Jason A.; Rothblatt, Martine; Boyden, Edward S.; Eidbo, Elling; Lee, W. P.Andrew; Pomahac, Bohdan; Brandacher, Gerald; Weinstock, David M.; Elliott, Gloria; Nelson, David; Acker, Jason P.; Uygun, Korkut; Schmalz, Boris; Weegman, Brad P.; Tocchio, Alessandro; Fahy, Greg M.; Storey, Kenneth B.; Rubinsky, Boris; Bischof, John; Elliott, Janet A.W.; Woodruff, Teresa K.; Morris, G. John; Demirci, Utkan; Brockbank, Kelvin G.M.; Woods, Erik J.; Ben, Robert N.; Baust, John G.; Gao, Dayong; Fuller, Barry; Rabin, Yoed; Kravitz, David C.; Taylor, Michael J.; Toner, Mehmet.

In: Nature biotechnology, Vol. 35, No. 6, 07.06.2017, p. 530-542.

Research output: Contribution to journalReview article

Giwa, S, Lewis, JK, Alvarez, L, Langer, R, Roth, AE, Church, GM, Markmann, JF, Sachs, DH, Chandraker, A, Wertheim, JA, Rothblatt, M, Boyden, ES, Eidbo, E, Lee, WPA, Pomahac, B, Brandacher, G, Weinstock, DM, Elliott, G, Nelson, D, Acker, JP, Uygun, K, Schmalz, B, Weegman, BP, Tocchio, A, Fahy, GM, Storey, KB, Rubinsky, B, Bischof, J, Elliott, JAW, Woodruff, TK, Morris, GJ, Demirci, U, Brockbank, KGM, Woods, EJ, Ben, RN, Baust, JG, Gao, D, Fuller, B, Rabin, Y, Kravitz, DC, Taylor, MJ & Toner, M 2017, 'The promise of organ and tissue preservation to transform medicine', Nature biotechnology, vol. 35, no. 6, pp. 530-542. https://doi.org/10.1038/nbt.3889
Giwa S, Lewis JK, Alvarez L, Langer R, Roth AE, Church GM et al. The promise of organ and tissue preservation to transform medicine. Nature biotechnology. 2017 Jun 7;35(6):530-542. https://doi.org/10.1038/nbt.3889
Giwa, Sebastian ; Lewis, Jedediah K. ; Alvarez, Luis ; Langer, Robert ; Roth, Alvin E. ; Church, George M. ; Markmann, James F. ; Sachs, David H. ; Chandraker, Anil ; Wertheim, Jason A. ; Rothblatt, Martine ; Boyden, Edward S. ; Eidbo, Elling ; Lee, W. P.Andrew ; Pomahac, Bohdan ; Brandacher, Gerald ; Weinstock, David M. ; Elliott, Gloria ; Nelson, David ; Acker, Jason P. ; Uygun, Korkut ; Schmalz, Boris ; Weegman, Brad P. ; Tocchio, Alessandro ; Fahy, Greg M. ; Storey, Kenneth B. ; Rubinsky, Boris ; Bischof, John ; Elliott, Janet A.W. ; Woodruff, Teresa K. ; Morris, G. John ; Demirci, Utkan ; Brockbank, Kelvin G.M. ; Woods, Erik J. ; Ben, Robert N. ; Baust, John G. ; Gao, Dayong ; Fuller, Barry ; Rabin, Yoed ; Kravitz, David C. ; Taylor, Michael J. ; Toner, Mehmet. / The promise of organ and tissue preservation to transform medicine. In: Nature biotechnology. 2017 ; Vol. 35, No. 6. pp. 530-542.
@article{eef23ba3673c4fa28f68b7c746eb63ea,
title = "The promise of organ and tissue preservation to transform medicine",
abstract = "The ability to replace organs and tissues on demand could save or improve millions of lives each year globally and create public health benefits on par with curing cancer. Unmet needs for organ and tissue preservation place enormous logistical limitations on transplantation, regenerative medicine, drug discovery, and a variety of rapidly advancing areas spanning biomedicine. A growing coalition of researchers, clinicians, advocacy organizations, academic institutions, and other stakeholders has assembled to address the unmet need for preservation advances, outlining remaining challenges and identifying areas of underinvestment and untapped opportunities. Meanwhile, recent discoveries provide proofs of principle for breakthroughs in a family of research areas surrounding biopreservation. These developments indicate that a new paradigm, integrating multiple existing preservation approaches and new technologies that have flourished in the past 10 years, could transform preservation research. Capitalizing on these opportunities will require engagement across many research areas and stakeholder groups. A coordinated effort is needed to expedite preservation advances that can transform several areas of medicine and medical science.",
author = "Sebastian Giwa and Lewis, {Jedediah K.} and Luis Alvarez and Robert Langer and Roth, {Alvin E.} and Church, {George M.} and Markmann, {James F.} and Sachs, {David H.} and Anil Chandraker and Wertheim, {Jason A.} and Martine Rothblatt and Boyden, {Edward S.} and Elling Eidbo and Lee, {W. P.Andrew} and Bohdan Pomahac and Gerald Brandacher and Weinstock, {David M.} and Gloria Elliott and David Nelson and Acker, {Jason P.} and Korkut Uygun and Boris Schmalz and Weegman, {Brad P.} and Alessandro Tocchio and Fahy, {Greg M.} and Storey, {Kenneth B.} and Boris Rubinsky and John Bischof and Elliott, {Janet A.W.} and Woodruff, {Teresa K.} and Morris, {G. John} and Utkan Demirci and Brockbank, {Kelvin G.M.} and Woods, {Erik J.} and Ben, {Robert N.} and Baust, {John G.} and Dayong Gao and Barry Fuller and Yoed Rabin and Kravitz, {David C.} and Taylor, {Michael J.} and Mehmet Toner",
year = "2017",
month = "6",
day = "7",
doi = "10.1038/nbt.3889",
language = "English (US)",
volume = "35",
pages = "530--542",
journal = "Biotechnology",
issn = "1087-0156",
publisher = "Nature Publishing Group",
number = "6",

}

TY - JOUR

T1 - The promise of organ and tissue preservation to transform medicine

AU - Giwa, Sebastian

AU - Lewis, Jedediah K.

AU - Alvarez, Luis

AU - Langer, Robert

AU - Roth, Alvin E.

AU - Church, George M.

AU - Markmann, James F.

AU - Sachs, David H.

AU - Chandraker, Anil

AU - Wertheim, Jason A.

AU - Rothblatt, Martine

AU - Boyden, Edward S.

AU - Eidbo, Elling

AU - Lee, W. P.Andrew

AU - Pomahac, Bohdan

AU - Brandacher, Gerald

AU - Weinstock, David M.

AU - Elliott, Gloria

AU - Nelson, David

AU - Acker, Jason P.

AU - Uygun, Korkut

AU - Schmalz, Boris

AU - Weegman, Brad P.

AU - Tocchio, Alessandro

AU - Fahy, Greg M.

AU - Storey, Kenneth B.

AU - Rubinsky, Boris

AU - Bischof, John

AU - Elliott, Janet A.W.

AU - Woodruff, Teresa K.

AU - Morris, G. John

AU - Demirci, Utkan

AU - Brockbank, Kelvin G.M.

AU - Woods, Erik J.

AU - Ben, Robert N.

AU - Baust, John G.

AU - Gao, Dayong

AU - Fuller, Barry

AU - Rabin, Yoed

AU - Kravitz, David C.

AU - Taylor, Michael J.

AU - Toner, Mehmet

PY - 2017/6/7

Y1 - 2017/6/7

N2 - The ability to replace organs and tissues on demand could save or improve millions of lives each year globally and create public health benefits on par with curing cancer. Unmet needs for organ and tissue preservation place enormous logistical limitations on transplantation, regenerative medicine, drug discovery, and a variety of rapidly advancing areas spanning biomedicine. A growing coalition of researchers, clinicians, advocacy organizations, academic institutions, and other stakeholders has assembled to address the unmet need for preservation advances, outlining remaining challenges and identifying areas of underinvestment and untapped opportunities. Meanwhile, recent discoveries provide proofs of principle for breakthroughs in a family of research areas surrounding biopreservation. These developments indicate that a new paradigm, integrating multiple existing preservation approaches and new technologies that have flourished in the past 10 years, could transform preservation research. Capitalizing on these opportunities will require engagement across many research areas and stakeholder groups. A coordinated effort is needed to expedite preservation advances that can transform several areas of medicine and medical science.

AB - The ability to replace organs and tissues on demand could save or improve millions of lives each year globally and create public health benefits on par with curing cancer. Unmet needs for organ and tissue preservation place enormous logistical limitations on transplantation, regenerative medicine, drug discovery, and a variety of rapidly advancing areas spanning biomedicine. A growing coalition of researchers, clinicians, advocacy organizations, academic institutions, and other stakeholders has assembled to address the unmet need for preservation advances, outlining remaining challenges and identifying areas of underinvestment and untapped opportunities. Meanwhile, recent discoveries provide proofs of principle for breakthroughs in a family of research areas surrounding biopreservation. These developments indicate that a new paradigm, integrating multiple existing preservation approaches and new technologies that have flourished in the past 10 years, could transform preservation research. Capitalizing on these opportunities will require engagement across many research areas and stakeholder groups. A coordinated effort is needed to expedite preservation advances that can transform several areas of medicine and medical science.

UR - http://www.scopus.com/inward/record.url?scp=85020430282&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020430282&partnerID=8YFLogxK

U2 - 10.1038/nbt.3889

DO - 10.1038/nbt.3889

M3 - Review article

VL - 35

SP - 530

EP - 542

JO - Biotechnology

JF - Biotechnology

SN - 1087-0156

IS - 6

ER -