TY - JOUR
T1 - The production of experimental glomerulonephritis in the rat
AU - Crosson, J. T.
AU - Lubowitz, H.
AU - Mazumdar, D. C.
AU - Weisser, F.
AU - Lang, S.
AU - Rolf, D.
AU - Germuth, F. G.
PY - 1974
Y1 - 1974
N2 - A reproducible method of producing a chronic obliterative glomerulonephritis in the rat using a modification of the standard nephrotoxic serum nephritis model was found, which involves injections of anti rat kidney antibody followed by antibody directed against the nephrotoxic antiserum. Massive proteinuria, azotemia, hypertension, and occasionally a nephrotic syndrome develop within 2 to 8 wk following the last injection. At this time, the animals are suitable for various physiologic studies and a glomerular lesion characterized by capillary wall thickening, extensive tuft sclerosis, focal fibrinoid necrosis, and crescent formation is present in a high percentage of animals. Immunofluorescent and electron microscopic studies show that an antibasement membrane nephritis is the primary lesion, through the possibility of a superimposed immune complex disease cannot be excluded. Close correlation is noted between the histologic severity of the lesion and the degree of azotemia.
AB - A reproducible method of producing a chronic obliterative glomerulonephritis in the rat using a modification of the standard nephrotoxic serum nephritis model was found, which involves injections of anti rat kidney antibody followed by antibody directed against the nephrotoxic antiserum. Massive proteinuria, azotemia, hypertension, and occasionally a nephrotic syndrome develop within 2 to 8 wk following the last injection. At this time, the animals are suitable for various physiologic studies and a glomerular lesion characterized by capillary wall thickening, extensive tuft sclerosis, focal fibrinoid necrosis, and crescent formation is present in a high percentage of animals. Immunofluorescent and electron microscopic studies show that an antibasement membrane nephritis is the primary lesion, through the possibility of a superimposed immune complex disease cannot be excluded. Close correlation is noted between the histologic severity of the lesion and the degree of azotemia.
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M3 - Article
C2 - 4137995
AN - SCOPUS:0016293809
SN - 0003-9985
VL - 98
SP - 344
EP - 350
JO - Archives of Pathology and Laboratory Medicine
JF - Archives of Pathology and Laboratory Medicine
IS - 5
ER -