TY - JOUR
T1 - The primary cilium
T2 - Its role as a tumor suppressor organelle
AU - Peixoto, Estanislao
AU - Richard, Seth
AU - Pant, Kishor
AU - Biswas, Aalekhya Sharma
AU - Gradilone, Sergio A.
N1 - Funding Information:
This work was supported by National Institutes of Health Grant, United States, R01CA183764 (to S.A.G.)
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/5
Y1 - 2020/5
N2 - The primary cilium is an organelle that nearly all cells within the body contain. Its function is to sense the extracellular environment through its abundance of receptors and linked signaling pathways, working as an antenna. Ciliary defects lead to different pathologies. In particular, many tumors lose primary cilia, and this is linked with negative implications for the cell such as an increase in malignancy. In this work we will go through the knowledge of the role of primary cilia in normal conditions, how it is involved in diverse signaling pathways, and in disease, particularly in cancer, highlighting its tumor suppressor properties.
AB - The primary cilium is an organelle that nearly all cells within the body contain. Its function is to sense the extracellular environment through its abundance of receptors and linked signaling pathways, working as an antenna. Ciliary defects lead to different pathologies. In particular, many tumors lose primary cilia, and this is linked with negative implications for the cell such as an increase in malignancy. In this work we will go through the knowledge of the role of primary cilia in normal conditions, how it is involved in diverse signaling pathways, and in disease, particularly in cancer, highlighting its tumor suppressor properties.
KW - Cancer
KW - HDAC6
KW - Primary cilia
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U2 - 10.1016/j.bcp.2020.113906
DO - 10.1016/j.bcp.2020.113906
M3 - Review article
C2 - 32169416
AN - SCOPUS:85081716190
SN - 0006-2952
VL - 175
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
M1 - 113906
ER -
