The primary cilium: Its role as a tumor suppressor organelle

Estanislao Peixoto, Seth Richard, Kishor Pant, Aalekhya Biswas, Sergio A. Gradilone

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

The primary cilium is an organelle that nearly all cells within the body contain. Its function is to sense the extracellular environment through its abundance of receptors and linked signaling pathways, working as an antenna. Ciliary defects lead to different pathologies. In particular, many tumors lose primary cilia, and this is linked with negative implications for the cell such as an increase in malignancy. In this work we will go through the knowledge of the role of primary cilia in normal conditions, how it is involved in diverse signaling pathways, and in disease, particularly in cancer, highlighting its tumor suppressor properties.

Original languageEnglish (US)
Article number113906
JournalBiochemical Pharmacology
Volume175
DOIs
StatePublished - May 2020

Bibliographical note

Funding Information:
This work was supported by National Institutes of Health Grant, United States, R01CA183764 (to S.A.G.)

Publisher Copyright:
© 2020 Elsevier Inc.

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Keywords

  • Cancer
  • HDAC6
  • Primary cilia

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