The Presenilin-1 δE9 Mutation Results in Reduced γ-Secretase Activity, but Not Total Loss of PS1 Function, in Isogenic Human Stem Cells

Grace Woodruff, Jessica E. Young, Fernando J. Martinez, Floyd Buen, Athurva Gore, Jennifer Kinaga, Zhe Li, Shauna H. Yuan, Kun Zhang, Lawrence S.B. Goldstein

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160 Scopus citations

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Biochemistry, Genetics and Molecular Biology