The potentiation of spinal analgesia by leucine enkephalin

Alice A. Larson, Jeffrey L. Vaught, A. E. Takemori

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In two strains of rats, intrathecal administration of morphine and met-enkephalin was found to produce a dose-dependent analgesic effect as measured by the tail-flick assay. Prior administration of leu-enkephalin at a dose which had no analgesic effect was found to reduce significantly the analgesic ED50 of both morphine and met-enkephalin. Met-enkephalin pretreatment, at a similar sub-analgesic dose, was without effect. Thus, a differential interaction of the enkephalins with morphine is evident at spinal structures.

Original languageEnglish (US)
Pages (from-to)381-383
Number of pages3
JournalEuropean Journal of Pharmacology
Issue number4
StatePublished - Feb 22 1980


  • Analgesia
  • Enkephalins
  • Interactions
  • Morphine


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