Abstract
Photodynamic therapy (PDT) has been shown to be an effective locally ablative anti-cancer treatment that has the additional advantage of inducing tumor-directed immune response. We hypothesized that PDT could be combined with anti-transforming growth factor (TGF) beta antibody that does not significantly affect the population of cytotoxic T lymphocytes (CTL) but at the same time, has the potential to decrease the immunosuppressive effects of regulatory T-cells (Treg) mediated by TGF beta. This hypothesis was tested with aTGF-beta antibody combined with BPD-mediated PDT in a BALB/c renal cell carcinoma model. Evidence of positive benefits of the combination therapy over individual treatments alone was obtained.
| Original language | English (US) |
|---|---|
| Title of host publication | Biophotonics and Immune Responses VI |
| DOIs | |
| State | Published - 2011 |
| Event | Biophotonics and Immune Responses VI - San Francisco, CA, United States Duration: Jan 23 2011 → Jan 24 2011 |
Publication series
| Name | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
|---|---|
| Volume | 7900 |
| ISSN (Print) | 1605-7422 |
Conference
| Conference | Biophotonics and Immune Responses VI |
|---|---|
| Country/Territory | United States |
| City | San Francisco, CA |
| Period | 1/23/11 → 1/24/11 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Anti-tumor immunity
- Kidney cancer
- Photodynamic therapy
- Regulatory T-cells
- Transforming growth factor beta
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