The potential role of functional inhibition of T regulatory cells by anti-TGFβ antibody in photodynamic therapy of renal cancer

Pawel Mroz, Michael R. Hamblin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Photodynamic therapy (PDT) has been shown to be an effective locally ablative anti-cancer treatment that has the additional advantage of inducing tumor-directed immune response. We hypothesized that PDT could be combined with anti-transforming growth factor (TGF) beta antibody that does not significantly affect the population of cytotoxic T lymphocytes (CTL) but at the same time, has the potential to decrease the immunosuppressive effects of regulatory T-cells (Treg) mediated by TGF beta. This hypothesis was tested with aTGF-beta antibody combined with BPD-mediated PDT in a BALB/c renal cell carcinoma model. Evidence of positive benefits of the combination therapy over individual treatments alone was obtained.

Original languageEnglish (US)
Title of host publicationBiophotonics and Immune Responses VI
Volume7900
DOIs
StatePublished - Apr 14 2011
EventBiophotonics and Immune Responses VI - San Francisco, CA, United States
Duration: Jan 23 2011Jan 24 2011

Other

OtherBiophotonics and Immune Responses VI
CountryUnited States
CitySan Francisco, CA
Period1/23/111/24/11

Fingerprint

Photodynamic therapy
Kidney Neoplasms
Photochemotherapy
Transforming Growth Factors
Regulatory T-Lymphocytes
antibodies
Antibodies
therapy
T-cells
cancer
beta factor
Transforming Growth Factor beta
cells
Oncology
Cytotoxic T-Lymphocytes
Immunosuppressive Agents
Renal Cell Carcinoma
Tumors
lymphocytes
Neoplasms

Keywords

  • Anti-tumor immunity
  • Kidney cancer
  • Photodynamic therapy
  • Regulatory T-cells
  • Transforming growth factor beta

Cite this

The potential role of functional inhibition of T regulatory cells by anti-TGFβ antibody in photodynamic therapy of renal cancer. / Mroz, Pawel; Hamblin, Michael R.

Biophotonics and Immune Responses VI. Vol. 7900 2011. 790003.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Mroz, P & Hamblin, MR 2011, The potential role of functional inhibition of T regulatory cells by anti-TGFβ antibody in photodynamic therapy of renal cancer. in Biophotonics and Immune Responses VI. vol. 7900, 790003, Biophotonics and Immune Responses VI, San Francisco, CA, United States, 1/23/11. https://doi.org/10.1117/12.876523
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