The Physiology of Cardiopulmonary Resuscitation

Keith G. Lurie, Edward C. Nemergut, Demetris Yannopoulos, Michael Sweeney

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


Outcomes after cardiac arrest remain poor more than a half a century after closed chest cardiopulmonary resuscitation (CPR) was first described. This review article is focused on recent insights into the physiology of blood flow to the heart and brain during CPR. Over the past 20 years, a greater understanding of heart-brain-lung interactions has resulted in novel resuscitation methods and technologies that significantly improve outcomes from cardiac arrest. This article highlights the importance of attention to CPR quality, recent approaches to regulate intrathoracic pressure to improve cerebral and systemic perfusion, and ongoing research related to the ways to mitigate reperfusion injury during CPR. Taken together, these new approaches in adult and pediatric patients provide an innovative, physiologically based road map to increase survival and quality of life after cardiac arrest.

Original languageEnglish (US)
Pages (from-to)767-783
Number of pages17
JournalAnesthesia and Analgesia
Issue number3
StatePublished - Mar 1 2016

PubMed: MeSH publication types

  • Journal Article
  • Review


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