The Physics of Hyperpolarized Gas MRI

B. M. Goodson; K. Ranta; J. G. Skinner; A. M. Coffey; P. Nikolaou; M. Gemeinhardt; D. Anthony; S. Stephenson; S. Hardy; J. Owers-Bradley; M. J. Barlow; E. Y. Chekmenev

doi:10.1016/B978-0-12-803675-4.00002-6

The Physics of Hyperpolarized Gas MRI

B. M. Goodson
, K. Ranta
, J. G. Skinner
, A. M. Coffey
, P. Nikolaou
, M. Gemeinhardt
, D. Anthony
, S. Stephenson
, S. Hardy
, J. Owers-Bradley
, M. J. Barlow
, E. Y. Chekmenev

Research output: Chapter in Book/Report/Conference proceeding › Chapter

9 Scopus citations

Abstract

This chapter introduces the physical principles underlying hyperpolarized (HP) gas magnetic resonance. The properties of such HP gases, including spin I?1/2 noble gas isotopes and low molecular-mass gases like propane, are introduced in the context of biomedical applications. Of particular interest are mechanisms of relaxation and contrast, and the ramifications of using HP gases in magnetic resonance imaging studies. The primary technologies for producing such HP gases are also introduced and described, including spin-exchange optical pumping (SEOP), metastability-exchange optical pumping (MEOP), "brute-force" polarization (BFP), dynamic nuclear polarization (DNP), and parahydrogen-induced polarization (PHIP). The advantages, limitations, and outlooks for such approaches are discussed.

Original language	English (US)
Title of host publication	Hyperpolarized and Inert Gas MRI
Subtitle of host publication	From Technology to Application in Research and Medicine
Publisher	Elsevier Inc.
Pages	23-46
Number of pages	24
ISBN (Electronic)	9780128037041
ISBN (Print)	9780128036754
DOIs	https://doi.org/10.1016/B978-0-12-803675-4.00002-6
State	Published - 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Inc. All rights reserved.

Keywords

DNP
Helium
Hyperpolarized xenon
Hyperpolarizer
Krypton
MEOP
Parahydrogen
PHIP
Propane
SEOP

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10.1016/B978-0-12-803675-4.00002-6

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Goodson, B. M., Ranta, K., Skinner, J. G., Coffey, A. M., Nikolaou, P., Gemeinhardt, M., Anthony, D., Stephenson, S., Hardy, S., Owers-Bradley, J., Barlow, M. J., & Chekmenev, E. Y. (2017). The Physics of Hyperpolarized Gas MRI. In Hyperpolarized and Inert Gas MRI: From Technology to Application in Research and Medicine (pp. 23-46). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-803675-4.00002-6

Goodson, BM, Ranta, K, Skinner, JG, Coffey, AM, Nikolaou, P, Gemeinhardt, M, Anthony, D, Stephenson, S, Hardy, S, Owers-Bradley, J, Barlow, MJ & Chekmenev, EY 2017, The Physics of Hyperpolarized Gas MRI. in Hyperpolarized and Inert Gas MRI: From Technology to Application in Research and Medicine. Elsevier Inc., pp. 23-46. https://doi.org/10.1016/B978-0-12-803675-4.00002-6

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abstract = "This chapter introduces the physical principles underlying hyperpolarized (HP) gas magnetic resonance. The properties of such HP gases, including spin I?1/2 noble gas isotopes and low molecular-mass gases like propane, are introduced in the context of biomedical applications. Of particular interest are mechanisms of relaxation and contrast, and the ramifications of using HP gases in magnetic resonance imaging studies. The primary technologies for producing such HP gases are also introduced and described, including spin-exchange optical pumping (SEOP), metastability-exchange optical pumping (MEOP), {"}brute-force{"} polarization (BFP), dynamic nuclear polarization (DNP), and parahydrogen-induced polarization (PHIP). The advantages, limitations, and outlooks for such approaches are discussed.",

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author = "Goodson, \{B. M.\} and K. Ranta and Skinner, \{J. G.\} and Coffey, \{A. M.\} and P. Nikolaou and M. Gemeinhardt and D. Anthony and S. Stephenson and S. Hardy and J. Owers-Bradley and Barlow, \{M. J.\} and Chekmenev, \{E. Y.\}",

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doi = "10.1016/B978-0-12-803675-4.00002-6",

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AU - Goodson, B. M.

AU - Ranta, K.

AU - Skinner, J. G.

AU - Coffey, A. M.

AU - Nikolaou, P.

AU - Gemeinhardt, M.

AU - Anthony, D.

AU - Stephenson, S.

AU - Hardy, S.

AU - Owers-Bradley, J.

AU - Barlow, M. J.

AU - Chekmenev, E. Y.

PY - 2017

Y1 - 2017

N2 - This chapter introduces the physical principles underlying hyperpolarized (HP) gas magnetic resonance. The properties of such HP gases, including spin I?1/2 noble gas isotopes and low molecular-mass gases like propane, are introduced in the context of biomedical applications. Of particular interest are mechanisms of relaxation and contrast, and the ramifications of using HP gases in magnetic resonance imaging studies. The primary technologies for producing such HP gases are also introduced and described, including spin-exchange optical pumping (SEOP), metastability-exchange optical pumping (MEOP), "brute-force" polarization (BFP), dynamic nuclear polarization (DNP), and parahydrogen-induced polarization (PHIP). The advantages, limitations, and outlooks for such approaches are discussed.

AB - This chapter introduces the physical principles underlying hyperpolarized (HP) gas magnetic resonance. The properties of such HP gases, including spin I?1/2 noble gas isotopes and low molecular-mass gases like propane, are introduced in the context of biomedical applications. Of particular interest are mechanisms of relaxation and contrast, and the ramifications of using HP gases in magnetic resonance imaging studies. The primary technologies for producing such HP gases are also introduced and described, including spin-exchange optical pumping (SEOP), metastability-exchange optical pumping (MEOP), "brute-force" polarization (BFP), dynamic nuclear polarization (DNP), and parahydrogen-induced polarization (PHIP). The advantages, limitations, and outlooks for such approaches are discussed.

KW - DNP

KW - Helium

KW - Hyperpolarized xenon

KW - Hyperpolarizer

KW - Krypton

KW - MEOP

KW - Parahydrogen

KW - PHIP

KW - Propane

KW - SEOP

UR - https://www.scopus.com/pages/publications/85020382005

UR - https://www.scopus.com/pages/publications/85020382005#tab=citedBy

U2 - 10.1016/B978-0-12-803675-4.00002-6

DO - 10.1016/B978-0-12-803675-4.00002-6

M3 - Chapter

AN - SCOPUS:85020382005

SN - 9780128036754

SP - 23

EP - 46

BT - Hyperpolarized and Inert Gas MRI

PB - Elsevier Inc.

ER -

The Physics of Hyperpolarized Gas MRI

Abstract

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