The periaqueductal gray-raphe magnus projection contains somatostatin, neurotensin and serotonin but not cholecystokinin

Alvin J. Beitz, R. David Shepard, William E. Wells

Research output: Contribution to journalArticlepeer-review

97 Scopus citations

Abstract

The retrograde transport-HRP-immunocytochemical technique was employed to ascertain if the periaqueductal gray-raphe magnus projection arises from neurons containing somatostatin, neurotensi, serotonin or cholecystokinin. Following HRP injections into the raphe magnus (NRM) double-labeled cells containing HRP reaction product and somatostatin-, neurotensin- or serotonin-like immunoreactivity were identified in the midbrain periaqueductal gray (PAG). No cholecystokinin-like immunoreactive double-labeled neurons were found in the PAG. These results indicate that the PAG-NRM pathway contains somatostatin, neurotensin and serotonin but not cholecystokinin.

Original languageEnglish (US)
Pages (from-to)132-137
Number of pages6
JournalBrain Research
Volume261
Issue number1
DOIs
StatePublished - Feb 14 1983

Keywords

  • cholecystokinin
  • neurotensin
  • nucleus raphe magnus
  • serotonin
  • somatostatin

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