TY - JOUR
T1 - The pathogenesis of Epstein-Barr virus persistent infection
AU - Thorley-Lawson, David A.
AU - Hawkins, Jared B.
AU - Tracy, Sean I.
AU - Shapiro, Michael
N1 - Funding Information:
This work was supported by Public Health Service grants R01 CA65883 , R01 AI18757 and RO1 AI062989 to DATL and K25-AI079404 to MS.
PY - 2013/6
Y1 - 2013/6
N2 - Epstein-Barr virus (EBV) maintains a lifelong infection. According to the germinal center model (GCM), latently infected B cells transit the germinal center (GC) to become resting memory cells. Here, the virus resides quiescently, occasionally reactivating to infect new B cells, completing the cycle of infection. The GCM remains the only model that explains EBV biology and the pathogenesis of lymphoma. Recent work suggests modifications to the model notably that the virus contributes only modestly to the GC process and predictions from mathematical models that quiescence within memory B cells shapes the overall structure of viral infection but is not essential for persistence. Rather, it is the cycle of infection which allows viral persistence at the very low levels observed.
AB - Epstein-Barr virus (EBV) maintains a lifelong infection. According to the germinal center model (GCM), latently infected B cells transit the germinal center (GC) to become resting memory cells. Here, the virus resides quiescently, occasionally reactivating to infect new B cells, completing the cycle of infection. The GCM remains the only model that explains EBV biology and the pathogenesis of lymphoma. Recent work suggests modifications to the model notably that the virus contributes only modestly to the GC process and predictions from mathematical models that quiescence within memory B cells shapes the overall structure of viral infection but is not essential for persistence. Rather, it is the cycle of infection which allows viral persistence at the very low levels observed.
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U2 - 10.1016/j.coviro.2013.04.005
DO - 10.1016/j.coviro.2013.04.005
M3 - Review article
C2 - 23683686
AN - SCOPUS:84880264918
SN - 1879-6257
VL - 3
SP - 227
EP - 232
JO - Current Opinion in Virology
JF - Current Opinion in Virology
IS - 3
ER -
