The parietal memory network activates similarly for true and associative false recognition elicited via the DRM procedure

Kathleen B. McDermott, Adrian W. Gilmore, Steven M. Nelson, Jason M. Watson, Jeffrey G. Ojemann

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Neuroimaging investigations of human memory encoding and retrieval have revealed that multiple regions of parietal cortex contribute to memory. Recently, a sparse network of regions within parietal cortex has been identified using resting state functional connectivity (MRI techniques). The regions within this network exhibit consistent task-related responses during memory formation and retrieval, leading to its being called the parietal memory network (PMN). Among its signature patterns are: deactivation during initial experience with an item (e.g., encoding); activation during subsequent repetitions (e.g., at retrieval); greater activation for successfully retrieved familiar words than novel words (e.g., hits relative to correctly-rejected lures). The question of interest here is whether novel words that are subjectively experienced as having been recently studied would elicit PMN activation similar to that of hits. That is, we compared old items correctly recognized to two types of novel items on a recognition test: those correctly identified as new and those incorrectly labeled as old due to their strong associative relation to the studied words (in the DRM false memory protocol). Subjective oldness plays a strong role in driving activation, as hits and false alarms activated similarly (and greater than correctly-rejected lures).

Original languageEnglish (US)
Pages (from-to)96-107
Number of pages12
JournalCortex
Volume87
DOIs
StatePublished - Feb 1 2017
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by grants from the McDonnell-Pew Program in Cognitive Neuroscience ( 99-29 CN-QUA.05 ), the National Science Foundation ( SES-0074848 ), the National Institutes of Health ( MH62514 ), and Dart Neuroscience LLC to KM. The authors appreciate the help of Sarah Lageman and Pooja Agarwal with data analysis and Jeff Berg in manuscript preparation.

Publisher Copyright:
© 2016 Elsevier Ltd

Keywords

  • DRM
  • False alarm
  • False memory
  • Retrieval success
  • fMRI

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