The paradoxical response of cardiac glycogen to oral casein hydrolysate in rats

Mary C Gannon, frank q Nuttall

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

In fasted rats, casein hydrolysate administration resulted in a marked increase in glycogen synthase I activity, no change in phosphorylase a and a marked decrease in glycogen concentration. This occurred with doses as small as 0.5 g/kg body weight. The major reason for an increase in synthase I appeared to be the reduced glycogen concentration, although insulin may play a role early in the time course. The decrease in glycogen in the absence of a change in phosphorylase a most likely is due to a decrease in an allosteric inhibitor. The nature of this inhibitor is unknown.

Original languageEnglish (US)
Pages (from-to)888-894
Number of pages7
JournalJournal of Nutrition
Volume118
Issue number7
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

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