The oxo/peroxo debate: A nonheme iron perspective

Lawrence Que

doi:10.1007/s00775-004-0574-8

The oxo/peroxo debate: A nonheme iron perspective

Lawrence Que

Chemistry (Twin Cities)

Research output: Contribution to journal › Review article › peer-review

48 Scopus citations

Abstract

The oxygen activation mechanisms proposed for nonheme iron systems generally follow the heme paradigm in invoking the involvement of iron-peroxo and iron-oxo species in their catalytic cycles. However, the nonheme ligand environments allow for end-on and side-on dioxygen coordination and impart greater flexibility in the modes of dioxygen activation. The currently available evidence for nonheme iron-peroxo and iron-oxo intermediates is summarized and discussed in light of the ongoing discussion on the nature of the oxidant(s) in heme enzymes.

Original language	English (US)
Pages (from-to)	684-690
Number of pages	7
Journal	Journal of Biological Inorganic Chemistry
Volume	9
Issue number	6
DOIs	https://doi.org/10.1007/s00775-004-0574-8
State	Published - Sep 2004

Bibliographical note

Funding Information:
Acknowledgements The work on nonheme iron enzymes and synthetic models thereof carried out in the Que laboratory has been generously supported by the National Institutes of Health (GM-33162 and GM-38767).

Keywords

Iron(III)-peroxo
Iron(IV)-oxo
Model compounds
Nonheme iron enzymes
Oxygen activation

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10.1007/s00775-004-0574-8

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title = "The oxo/peroxo debate: A nonheme iron perspective",

abstract = "The oxygen activation mechanisms proposed for nonheme iron systems generally follow the heme paradigm in invoking the involvement of iron-peroxo and iron-oxo species in their catalytic cycles. However, the nonheme ligand environments allow for end-on and side-on dioxygen coordination and impart greater flexibility in the modes of dioxygen activation. The currently available evidence for nonheme iron-peroxo and iron-oxo intermediates is summarized and discussed in light of the ongoing discussion on the nature of the oxidant(s) in heme enzymes.",

keywords = "Iron(III)-peroxo, Iron(IV)-oxo, Model compounds, Nonheme iron enzymes, Oxygen activation",

author = "Lawrence Que",

note = "Funding Information: Acknowledgements The work on nonheme iron enzymes and synthetic models thereof carried out in the Que laboratory has been generously supported by the National Institutes of Health (GM-33162 and GM-38767).",

year = "2004",

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doi = "10.1007/s00775-004-0574-8",

language = "English (US)",

volume = "9",

pages = "684--690",

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T2 - A nonheme iron perspective

AU - Que, Lawrence

N1 - Funding Information: Acknowledgements The work on nonheme iron enzymes and synthetic models thereof carried out in the Que laboratory has been generously supported by the National Institutes of Health (GM-33162 and GM-38767).

PY - 2004/9

Y1 - 2004/9

N2 - The oxygen activation mechanisms proposed for nonheme iron systems generally follow the heme paradigm in invoking the involvement of iron-peroxo and iron-oxo species in their catalytic cycles. However, the nonheme ligand environments allow for end-on and side-on dioxygen coordination and impart greater flexibility in the modes of dioxygen activation. The currently available evidence for nonheme iron-peroxo and iron-oxo intermediates is summarized and discussed in light of the ongoing discussion on the nature of the oxidant(s) in heme enzymes.

AB - The oxygen activation mechanisms proposed for nonheme iron systems generally follow the heme paradigm in invoking the involvement of iron-peroxo and iron-oxo species in their catalytic cycles. However, the nonheme ligand environments allow for end-on and side-on dioxygen coordination and impart greater flexibility in the modes of dioxygen activation. The currently available evidence for nonheme iron-peroxo and iron-oxo intermediates is summarized and discussed in light of the ongoing discussion on the nature of the oxidant(s) in heme enzymes.

KW - Iron(III)-peroxo

KW - Iron(IV)-oxo

KW - Model compounds

KW - Nonheme iron enzymes

KW - Oxygen activation

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DO - 10.1007/s00775-004-0574-8

M3 - Review article

C2 - 15300470

AN - SCOPUS:4644302003

SN - 0949-8257

VL - 9

SP - 684

EP - 690

JO - Journal of Biological Inorganic Chemistry

JF - Journal of Biological Inorganic Chemistry

IS - 6

ER -

The oxo/peroxo debate: A nonheme iron perspective

Abstract

Bibliographical note

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