The oxo/peroxo debate: A nonheme iron perspective

Research output: Contribution to journalReview article

48 Scopus citations


The oxygen activation mechanisms proposed for nonheme iron systems generally follow the heme paradigm in invoking the involvement of iron-peroxo and iron-oxo species in their catalytic cycles. However, the nonheme ligand environments allow for end-on and side-on dioxygen coordination and impart greater flexibility in the modes of dioxygen activation. The currently available evidence for nonheme iron-peroxo and iron-oxo intermediates is summarized and discussed in light of the ongoing discussion on the nature of the oxidant(s) in heme enzymes.

Original languageEnglish (US)
Pages (from-to)684-690
Number of pages7
JournalJournal of Biological Inorganic Chemistry
Issue number6
StatePublished - Sep 1 2004


  • Iron(III)-peroxo
  • Iron(IV)-oxo
  • Model compounds
  • Nonheme iron enzymes
  • Oxygen activation

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