The oxygen activation mechanisms proposed for nonheme iron systems generally follow the heme paradigm in invoking the involvement of iron-peroxo and iron-oxo species in their catalytic cycles. However, the nonheme ligand environments allow for end-on and side-on dioxygen coordination and impart greater flexibility in the modes of dioxygen activation. The currently available evidence for nonheme iron-peroxo and iron-oxo intermediates is summarized and discussed in light of the ongoing discussion on the nature of the oxidant(s) in heme enzymes.
Bibliographical noteFunding Information:
Acknowledgements The work on nonheme iron enzymes and synthetic models thereof carried out in the Que laboratory has been generously supported by the National Institutes of Health (GM-33162 and GM-38767).
- Model compounds
- Nonheme iron enzymes
- Oxygen activation