Abstract
The oxygen activation mechanisms proposed for nonheme iron systems generally follow the heme paradigm in invoking the involvement of iron-peroxo and iron-oxo species in their catalytic cycles. However, the nonheme ligand environments allow for end-on and side-on dioxygen coordination and impart greater flexibility in the modes of dioxygen activation. The currently available evidence for nonheme iron-peroxo and iron-oxo intermediates is summarized and discussed in light of the ongoing discussion on the nature of the oxidant(s) in heme enzymes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 684-690 |
| Number of pages | 7 |
| Journal | Journal of Biological Inorganic Chemistry |
| Volume | 9 |
| Issue number | 6 |
| DOIs | |
| State | Published - Sep 2004 |
Bibliographical note
Funding Information:Acknowledgements The work on nonheme iron enzymes and synthetic models thereof carried out in the Que laboratory has been generously supported by the National Institutes of Health (GM-33162 and GM-38767).
Keywords
- Iron(III)-peroxo
- Iron(IV)-oxo
- Model compounds
- Nonheme iron enzymes
- Oxygen activation