The oxo/peroxo debate: A nonheme iron perspective

Lawrence Que

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations


The oxygen activation mechanisms proposed for nonheme iron systems generally follow the heme paradigm in invoking the involvement of iron-peroxo and iron-oxo species in their catalytic cycles. However, the nonheme ligand environments allow for end-on and side-on dioxygen coordination and impart greater flexibility in the modes of dioxygen activation. The currently available evidence for nonheme iron-peroxo and iron-oxo intermediates is summarized and discussed in light of the ongoing discussion on the nature of the oxidant(s) in heme enzymes.

Original languageEnglish (US)
Pages (from-to)684-690
Number of pages7
JournalJournal of Biological Inorganic Chemistry
Issue number6
StatePublished - Sep 2004

Bibliographical note

Funding Information:
Acknowledgements The work on nonheme iron enzymes and synthetic models thereof carried out in the Que laboratory has been generously supported by the National Institutes of Health (GM-33162 and GM-38767).


  • Iron(III)-peroxo
  • Iron(IV)-oxo
  • Model compounds
  • Nonheme iron enzymes
  • Oxygen activation


Dive into the research topics of 'The oxo/peroxo debate: A nonheme iron perspective'. Together they form a unique fingerprint.

Cite this