TY - JOUR
T1 - The Oral-Lung Axis
T2 - The Impact of Oral Health on Lung Health
AU - Gaeckle, Nathaniel T
AU - Pragman, Alexa A
AU - Pendleton, Kathryn M.
AU - Baldomero, Arianne K.
AU - Criner, Gerard J.
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Poor oral health has long been recognized as a clinical risk factor for developing lung infections. Recent data using culture-independent techniques assessing the microbiome in healthy subjects have demonstrated that chronic microaspiration establishes a very similar microbial community between the mouth and lung, suggesting these 2 anatomic regions are closely intertwined. Dental disease is driven and aided by a dysbiosis in the oral microbiome, and evidence is mounting that implicates the microbiome in a variety of lung diseases including asthma, COPD, pulmonary fibrosis, and pneumonia. This review describes common dental conditions and potential mechanisms by which poor oral health may contribute to lung disease. We also review the current literature drawing associations between poor oral health and lung disease.
AB - Poor oral health has long been recognized as a clinical risk factor for developing lung infections. Recent data using culture-independent techniques assessing the microbiome in healthy subjects have demonstrated that chronic microaspiration establishes a very similar microbial community between the mouth and lung, suggesting these 2 anatomic regions are closely intertwined. Dental disease is driven and aided by a dysbiosis in the oral microbiome, and evidence is mounting that implicates the microbiome in a variety of lung diseases including asthma, COPD, pulmonary fibrosis, and pneumonia. This review describes common dental conditions and potential mechanisms by which poor oral health may contribute to lung disease. We also review the current literature drawing associations between poor oral health and lung disease.
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U2 - 10.4187/respcare.07332
DO - 10.4187/respcare.07332
M3 - Review article
C2 - 32156792
VL - 65
SP - 1211
EP - 1220
JO - Respiratory Care
JF - Respiratory Care
SN - 0020-1324
IS - 8
ER -