The number of cysteine residues per mole in apolipoprotein E is associated with the severity of PTSD re-experiencing symptoms

Carly K. Peterson; Lisa M. James; Samantha L. Anders; Brian E. Engdahl; Apost Olos P. Georgopoulos

doi:10.1176/appi.neuropsych.13090205

The number of cysteine residues per mole in apolipoprotein E is associated with the severity of PTSD re-experiencing symptoms

Carly K. Peterson, Lisa M. James, Samantha L. Anders, Brian E. Engdahl, Apost Olos P. Georgopoulos

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Apolipoprotien E (ApoE) is involved in critical neural functions and is associated with various neuropsychiatric disorders. ApoE exists in three isoforms that differ in the number of cysteine residues per mole (CysR/mole). This study evaluated associations between this informative ordinal biochemical scale (CysR/mole) and symptom severity in veterans with posttraumatic stress disorder (PTSD) or subthreshold PTSD. Results demonstrated a significant negative relationship between the CysR/mole and severity of PTSD re-experiencing symptoms, adjusted for trauma. The findings suggest a genetic influence on PTSD symptomatology and dovetail with recent advances regarding the molecular mechanisms underlying the differential effects of ApoE in the brain.

Original language	English (US)
Pages (from-to)	157-161
Number of pages	5
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	27
Issue number	2
DOIs	https://doi.org/10.1176/appi.neuropsych.13090205
State	Published - 2015

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© 2015, Journal of Neuropsychiatry and Clinical Neurosciences. All right reserved.

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abstract = "Apolipoprotien E (ApoE) is involved in critical neural functions and is associated with various neuropsychiatric disorders. ApoE exists in three isoforms that differ in the number of cysteine residues per mole (CysR/mole). This study evaluated associations between this informative ordinal biochemical scale (CysR/mole) and symptom severity in veterans with posttraumatic stress disorder (PTSD) or subthreshold PTSD. Results demonstrated a significant negative relationship between the CysR/mole and severity of PTSD re-experiencing symptoms, adjusted for trauma. The findings suggest a genetic influence on PTSD symptomatology and dovetail with recent advances regarding the molecular mechanisms underlying the differential effects of ApoE in the brain.",

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AU - Peterson, Carly K.

AU - James, Lisa M.

AU - Anders, Samantha L.

AU - Engdahl, Brian E.

AU - Georgopoulos, Apost Olos P.

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AB - Apolipoprotien E (ApoE) is involved in critical neural functions and is associated with various neuropsychiatric disorders. ApoE exists in three isoforms that differ in the number of cysteine residues per mole (CysR/mole). This study evaluated associations between this informative ordinal biochemical scale (CysR/mole) and symptom severity in veterans with posttraumatic stress disorder (PTSD) or subthreshold PTSD. Results demonstrated a significant negative relationship between the CysR/mole and severity of PTSD re-experiencing symptoms, adjusted for trauma. The findings suggest a genetic influence on PTSD symptomatology and dovetail with recent advances regarding the molecular mechanisms underlying the differential effects of ApoE in the brain.

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The number of cysteine residues per mole in apolipoprotein E is associated with the severity of PTSD re-experiencing symptoms

Abstract

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