The number of cysteine residues per mole in apolipoprotein E is associated with the severity of PTSD re-experiencing symptoms

Carly K. Peterson, Lisa M. James, Samantha L. Anders, Brian E. Engdahl, Apost Olos P. Georgopoulos

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Apolipoprotien E (ApoE) is involved in critical neural functions and is associated with various neuropsychiatric disorders. ApoE exists in three isoforms that differ in the number of cysteine residues per mole (CysR/mole). This study evaluated associations between this informative ordinal biochemical scale (CysR/mole) and symptom severity in veterans with posttraumatic stress disorder (PTSD) or subthreshold PTSD. Results demonstrated a significant negative relationship between the CysR/mole and severity of PTSD re-experiencing symptoms, adjusted for trauma. The findings suggest a genetic influence on PTSD symptomatology and dovetail with recent advances regarding the molecular mechanisms underlying the differential effects of ApoE in the brain.

Original languageEnglish (US)
Pages (from-to)157-161
Number of pages5
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume27
Issue number2
DOIs
StatePublished - Jan 1 2015

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