Abstract
Background: E2F1-induced apoptosis kills oncogene-stressed cells, and regulators of this process may act as tumor suppressors. Results: We identified UHRF2 in a functional screen for mediators of E2F1 induced apoptosis. Conclusion: UHRF2 binds directly to E2F1 and is required for E2F1 induction of apoptosis and expression of several important apoptosis inducers. Significance: UHRF2 is a suspected tumor suppressor and our work suggests an anti-tumor mechanism.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 23833-23843 |
| Number of pages | 11 |
| Journal | Journal of Biological Chemistry |
| Volume | 288 |
| Issue number | 33 |
| DOIs | |
| State | Published - Aug 16 2013 |
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