The membrane system that encloses genomic DNA is referred to as the nuclear envelope. However, with emerging roles in signaling and gene expression, these membranes clearly serve as more than just a physical barrier separating the nucleus and cytoplasm. Recent progress in our understanding of nuclear envelope architecture and composition has also revealed an intriguing connection between constituents of the nuclear envelope and human disease, providing further impetus to decipher this cellular structure and the dramatic remodeling process it undergoes with each cell division.
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We are grateful to Diana Lim for graphic design. We thank Jody Rosenblatt and Kathy Wilson for critical review and helpful comments. KSU is supported by National Institutes of Health (GM61275), the Huntsman Cancer Fund, and a Scholar Award from the Leukemia and Lymphoma Society. AJP acknowledges support from a University of Utah Graduate Research Fellowship.