The noninvasive electrical mapping of reanimated large mammalian hearts

Renee C. Brigham, David A. Ramirez, Tinen L Iles, Paul A. Iaizzo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Electroanatomical mapping systems are being utilized clinically for locating arrhythmias within a given patient's heart. Today, employed endocardial mapping systems are invasive and require extensive set-up time. Epicardial mapping systems, like CardioInsightTM from Medtronic, are noninvasive but require co-registration of electrodes to the heart, e.g. via a required Computed Tomography (CT) scan. This system has been used both clinically and in several laboratories in situ. The difficulties with in vitro uses are that the ex vivo perfused hearts lack an associated thoracic cavity, resulting in the possibility of inconsistent placement of electrodes, and poor conduction of epicardial signals. We are developing in our laboratory means to use the CardioInsightTM system on reanimated large mammalian hearts. Preliminary studies were conducted on swine hearts, but this system could be also be utilized with reanimated human hearts, making this research even more translatable. The use of this epicardial mapping system will allow for critical observations during pacing or ablation experiments and for collecting critical data for computational modeling.

Original languageEnglish (US)
Title of host publicationFrontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020
PublisherAmerican Society of Mechanical Engineers (ASME)
ISBN (Electronic)9780791883549
DOIs
StatePublished - 2020
Event2020 Design of Medical Devices Conference, DMD 2020 - Minneapolis, United States
Duration: Apr 6 2020Apr 9 2020

Publication series

NameFrontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020

Conference

Conference2020 Design of Medical Devices Conference, DMD 2020
CountryUnited States
CityMinneapolis
Period4/6/204/9/20

Bibliographical note

Funding Information:
Thank you to the Visible Heart Laboratories' graduate students and staff for their assistance.

Keywords

  • Cardiac ablation
  • Electroanatomical mapping
  • Electrophysiology
  • Epicardial mapping
  • Ex-vivo

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