The non specificity of specific nitric oxide synthase inhibitors

D. A. Peterson, D. C. Peterson, S. Archer, E. K. Weir

Research output: Contribution to journalArticlepeer-review

144 Scopus citations

Abstract

L-NAME (Nw-Nitro-L-arginine methylester) and L-NMMA (NG-Monomethyl-L-arginine, monoacetate) are used widely as nitric oxide (NO) synthase inhibitors. Because of their functional groups (alcohols, amines and carboxylates), it appeared that they could interact with iron in a variety of systems. Using three in vitro models we observed these two compounds had inhibitory effects on cytochrome C reduction by ferrous iron, by ferrous iron accelerated by an unsaturated fatty acid or by epinephrine. This suggests that L-NAME and L-NMMA could have effects in iron containing systems found intracellularly apart from their inhibition of (NO) synthesis.

Original languageEnglish (US)
Pages (from-to)797-801
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume187
Issue number2
DOIs
StatePublished - Sep 16 1992

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