The neuroendocrine and behavioral response to dextroamphetamine in normal individuals

C. S. Dommisse, S. C. Schulz, N. Narasimhachari, W. G. Blackard, R. M. Hamer

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Dextroamphetamine 30 mg and placebo were administered by mouth in a double-blind randomized cross-over trial to ten subjects. Behavior was assessed and blood samples analyzed for growth hormone (GH), prolactin (PRL), homovanillic acid (HVA), and amphetamine. There was a statistically significant increase in well-being following d-amphetamine as compared to baseline and placebo on both the Amphetamine Interview Rating Scale and the Hopkins Mood Scale. No subject became psychotic. There was a statistically significant increase in GH from baseline to peak following d-amphetamine ingestion. When compared to placebo, the increase in GH was invariable and statistically significant for the 90-min sampling. PRL decreased from baseline following both d-amphetamine and placebo and there was no significant drug-placebo difference. Serum HVA was measured at baseline and 120 min, for eight subjects. Six subjects had an increase in HVA following d-amphetamine but there was no significant drug effect.

Original languageEnglish (US)
Pages (from-to)1305-1315
Number of pages11
JournalBiological psychiatry
Volume19
Issue number9
StatePublished - 1984

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    Dommisse, C. S., Schulz, S. C., Narasimhachari, N., Blackard, W. G., & Hamer, R. M. (1984). The neuroendocrine and behavioral response to dextroamphetamine in normal individuals. Biological psychiatry, 19(9), 1305-1315.