The neurobiology of self-knowledge in depressed and self-injurious youth

Karina Quevedo, Jodi Martin, Hannah Scott, Garry Smyda, Jennifer H. Pfeifer

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

There is limited information regarding the neurobiology underlying non-suicidal self-injury (NSSI) in clinically-referred youth. However, the salience of disturbed interpersonal relationships and disrupted self-processing associated with NSSI suggests the neural basis of social processes as a key area for additional study. Adolescent participants (N=123; M=14.75 years, SD=1.64) were divided into three groups: NSSI plus depression diagnosis (NSSI), depression only (DEP), healthy controls (HC). In the scanner, participants completed an Interpersonal Self-Processing task by taking direct (own) and indirect (mothers', best friends', or classmates') perspectives regarding self-characteristics. Across all perspectives, NSSI showed higher BOLD activation in limbic areas, and anterior and posterior cortical midline structures versus DEP and HC, while HC showed greater activity in rostrolateral, frontal pole and occipital cortex than NSSI and DEP youth. Moreover, NSSI youth showed heightened responses in amygdala, hippocampus, parahippocampus, and fusiform when taking their mothers' perspective, which were negatively correlated with self-reports of the mother's support of adolescents' emotional distress in the NSSI group. NSSI youth also yielded greater precuneus and posterior cingulate cortex activity during indirect self-processing from their classmates' perspective. Findings suggest a role for disruptions in self- and emotion-processing, and conflicted social relationships in the neurobiology of NSSI among depressed adolescents.

Original languageEnglish (US)
Pages (from-to)145-155
Number of pages11
JournalPsychiatry Research - Neuroimaging
Volume254
DOIs
StatePublished - Aug 30 2016

Bibliographical note

Funding Information:
This research was supported by a NIMH , K01MH092601 and a NARSAD to the first author and a Social Sciences and Humanities Research Council of Canada Postdoctoral Fellowship to the second author. We are very grateful to Dr. Tom Zeffiro and Dr. Kathleen Thomas, who were key mentors and supporters of the first author's K award application.

Publisher Copyright:
© 2016 Elsevier Ireland Ltd

Keywords

  • Adolescence
  • Depression
  • Emotional invalidation
  • Limbic and cortical midline structures
  • Neuroimaging
  • Non-suicidal self-injury
  • Self-knowledge

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