The neurobiological characteristics of rapid eye movement (REM) sleep are candidate endophenotypes of depression, schizophrenia, mental retardation and dementia

Claude Gottesmann, Irving Gottesman

Research output: Contribution to journalReview articlepeer-review

88 Scopus citations

Abstract

Animal models are a promising method to approach the basic mechanisms of the neurobiological disturbances encountered in mental disorders. Depression is characterized by a decrease of REM sleep latency and an increase of rapid eye movement density. In schizophrenia, electrophysiological, tomographic, pharmacological and neurochemical activities are all encountered during REM sleep. Mental retardation and dementia are characterized by rather specific REM sleep disturbances. Identification of the genetic support for these abnormalities (endophenotypes) encountered during REM sleep could help to develop specific treatments.

Original languageEnglish (US)
Pages (from-to)237-250
Number of pages14
JournalProgress in Neurobiology
Volume81
Issue number4
DOIs
StatePublished - Mar 1 2007

Keywords

  • Dreaming
  • Mental illness
  • Paradoxical sleep

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