The multifaceted allosteric regulation of Aurora kinase A

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


The protein kinase Aurora A (AurA) is essential for the formation of bipolar mitotic spindles in all eukaryotic organisms. During spindle assembly, AurA is activated through two different pathways operating at centrosomes and on spindle microtubules. Recent studies have revealed that these pathways operate quite differently at the molecular level, activating AurA through multifaceted changes to the structure and dynamics of the kinase domain. These advances provide an intimate atomic-level view of the finely tuned regulatory control operating in protein kinases, revealing mechanisms of allosteric coop-erativity that provide graded levels of regulatory control, and a previously unanticipated mechanism for kinase activation by phosphorylation on the activation loop. Here, I review these advances in our understanding of AurA function, and discuss their implications for the use of allosteric small molecule inhibitors to address recently discovered roles of AurA in neuroblastoma, prostate cancer and melanoma.

Original languageEnglish (US)
Pages (from-to)2025-2042
Number of pages18
JournalBiochemical Journal
Issue number12
StatePublished - Jun 26 2018

Bibliographical note

Publisher Copyright:
© 2018 The Author(s).


Dive into the research topics of 'The multifaceted allosteric regulation of Aurora kinase A'. Together they form a unique fingerprint.

Cite this