Viruses possess elaborate defensive mechanisms to evade host innate immune responses. In this issue of Cell Host & Microbe, Stavrou et al. (2015) reveal how the murine leukemia virus uses a sugar-protein shield to protect from inevitable destruction by cellular innate immune factors including the APOBEC3 DNA mutating enzyme.
Bibliographical noteFunding Information:
R.S.H. laboratory virology studies are supported by NIAID R01 AI064046 and NIGMS P01 GM091743, and F.W.P. laboratory studies by NIGMS R01 GM110734.