TY - JOUR
T1 - The molecular pharmacology of estrogen receptor modulators
T2 - Implications for the treatment of breast cancer
AU - McDonnell, Donald P.
AU - Yee, Douglas
AU - Santen, Richard
AU - Osborne, Kent
AU - Brodie, Angela
PY - 2005/1/15
Y1 - 2005/1/15
N2 - In addition to physiologic activities in the reproductive, skeletal, and central nervous systems, estrogens have been shown to play important roles in the aberrant cell proliferation observed in breast and reproductive tract cancers. Not surprisingly, pharmaceuticals that target different steps in the estrogen signal transduction pathway have found widespread use in the treatment of a wide variety of estrogen-linked disorders. The goal of this review is to outline what is known about the molecular pharmacology of the estrogen receptor and discuss how this information can be used to guide selection of drugs for a particular therapeutic application, and identify new targets where pharmaceutical exploitation could yield novel therapeutics.
AB - In addition to physiologic activities in the reproductive, skeletal, and central nervous systems, estrogens have been shown to play important roles in the aberrant cell proliferation observed in breast and reproductive tract cancers. Not surprisingly, pharmaceuticals that target different steps in the estrogen signal transduction pathway have found widespread use in the treatment of a wide variety of estrogen-linked disorders. The goal of this review is to outline what is known about the molecular pharmacology of the estrogen receptor and discuss how this information can be used to guide selection of drugs for a particular therapeutic application, and identify new targets where pharmaceutical exploitation could yield novel therapeutics.
UR - http://www.scopus.com/inward/record.url?scp=12144262323&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=12144262323&partnerID=8YFLogxK
M3 - Article
C2 - 15701880
AN - SCOPUS:12144262323
SN - 1078-0432
VL - 11
SP - 871s-877s
JO - Clinical Cancer Research
JF - Clinical Cancer Research
IS - 2 II
ER -
