Abstract
An unusual tryptic peptide isolated from the protein, prothrombin, has recently been shown to contain at least a portion of the vitamin K dependent region of this protein. A modified glutamylserine dipeptide was isolated from proteolytic digests of this vitamin K dependent peptide and was characterized. It was unambiguously demonstrated that the glutamic acid of the glutamylserine was substituted by carboxylation of the γ (4) carbon atom. Presumably the incorporation of the second 4 carboxyl group is dependent on vitamin K.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 6347-6350 |
| Number of pages | 4 |
| Journal | Journal of Biological Chemistry |
| Volume | 249 |
| Issue number | 19 |
| State | Published - 1974 |