The mode of action of vitamin K. Identification of γ carboxyglutamic acid as a component of prothrombin

G. L. Nelsestuen, T. H. Zytkovicz, J. B. Howard

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Abstract

An unusual tryptic peptide isolated from the protein, prothrombin, has recently been shown to contain at least a portion of the vitamin K dependent region of this protein. A modified glutamylserine dipeptide was isolated from proteolytic digests of this vitamin K dependent peptide and was characterized. It was unambiguously demonstrated that the glutamic acid of the glutamylserine was substituted by carboxylation of the γ (4) carbon atom. Presumably the incorporation of the second 4 carboxyl group is dependent on vitamin K.

Original languageEnglish (US)
Pages (from-to)6347-6350
Number of pages4
JournalJournal of Biological Chemistry
Volume249
Issue number19
StatePublished - 1974

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