An unusual tryptic peptide isolated from the protein, prothrombin, has recently been shown to contain at least a portion of the vitamin K dependent region of this protein. A modified glutamylserine dipeptide was isolated from proteolytic digests of this vitamin K dependent peptide and was characterized. It was unambiguously demonstrated that the glutamic acid of the glutamylserine was substituted by carboxylation of the γ (4) carbon atom. Presumably the incorporation of the second 4 carboxyl group is dependent on vitamin K.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Biological Chemistry|
|State||Published - 1974|