The mitochondrial Ca2+ uniporter: Structure, function, and pharmacology

Jyotsna Mishra; Bong Sook Jhun; Stephen Hurst; Jin O-Uchi; György Csordás; Shey Shing Sheu

doi:10.1007/164_2017_1

The mitochondrial Ca²⁺ uniporter: Structure, function, and pharmacology

Jyotsna Mishra, Bong Sook Jhun, Stephen Hurst, Jin O-Uchi, György Csordás, Shey Shing Sheu

Research output: Chapter in Book/Report/Conference proceeding › Chapter

39 Scopus citations

Abstract

Mitochondrial Ca²⁺ uptake is crucial for an array of cellular functions while an imbalance can elicit cell death. In this chapter, we briefly reviewed the various modes of mitochondrial Ca²⁺ uptake and our current understanding of mitochondrial Ca²⁺ homeostasis in regards to cell physiology and pathophysiology. Further, this chapter focuses on the molecular identities, intracellular regulators as well as the pharmacology of mitochondrial Ca²⁺ uniporter complex.

Original language	English (US)
Title of host publication	Handbook of Experimental Pharmacology
Publisher	Springer New York LLC
DOIs	https://doi.org/10.1007/164_2017_1
State	Published - 2017
Externally published	Yes

Publication series

Name	Handbook of Experimental Pharmacology
Volume	240
ISSN (Print)	0171-2004
ISSN (Electronic)	1865-0325

Bibliographical note

Funding Information:
This work was partly supported by National Heart, Lung, and Blood Institute Grants 2R01 HL-093671 and HL-114760 (to S. S. Sheu), 1R01 HL-122124 (to G. Csordas and S. S. Sheu). American Heart Association Grant 16SDG27260248 (to J. O-Uchi).

Publisher Copyright:
© Springer International Publishing Switzerland 2016.

Keywords

Mitochondria
Mitochondrial Ca uniporter
Mitochondrial Ca uptake
Pharmacology

Publisher link

10.1007/164_2017_1

http://europepmc.org/articles/pmc5554456

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Cite this

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title = "The mitochondrial Ca2+ uniporter: Structure, function, and pharmacology",

abstract = "Mitochondrial Ca2+ uptake is crucial for an array of cellular functions while an imbalance can elicit cell death. In this chapter, we briefly reviewed the various modes of mitochondrial Ca2+ uptake and our current understanding of mitochondrial Ca2+ homeostasis in regards to cell physiology and pathophysiology. Further, this chapter focuses on the molecular identities, intracellular regulators as well as the pharmacology of mitochondrial Ca2+ uniporter complex.",

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AU - Hurst, Stephen

AU - O-Uchi, Jin

AU - Csordás, György

AU - Sheu, Shey Shing

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