The mitochondrial Ca2+ uniporter: Structure, function, and pharmacology

Jyotsna Mishra, Bong Sook Jhun, Stephen Hurst, Jin O-Uchi, György Csordás, Shey Shing Sheu

Research output: Chapter in Book/Report/Conference proceedingChapter

21 Scopus citations

Abstract

Mitochondrial Ca2+ uptake is crucial for an array of cellular functions while an imbalance can elicit cell death. In this chapter, we briefly reviewed the various modes of mitochondrial Ca2+ uptake and our current understanding of mitochondrial Ca2+ homeostasis in regards to cell physiology and pathophysiology. Further, this chapter focuses on the molecular identities, intracellular regulators as well as the pharmacology of mitochondrial Ca2+ uniporter complex.

Original languageEnglish (US)
Title of host publicationHandbook of Experimental Pharmacology
PublisherSpringer New York LLC
DOIs
StatePublished - 2017

Publication series

NameHandbook of Experimental Pharmacology
Volume240
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

Bibliographical note

Funding Information:
This work was partly supported by National Heart, Lung, and Blood Institute Grants 2R01 HL-093671 and HL-114760 (to S. S. Sheu), 1R01 HL-122124 (to G. Csordas and S. S. Sheu). American Heart Association Grant 16SDG27260248 (to J. O-Uchi).

Keywords

  • Mitochondria
  • Mitochondrial Ca uniporter
  • Mitochondrial Ca uptake
  • Pharmacology

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