Mitochondrial Ca2+ uptake is crucial for an array of cellular functions while an imbalance can elicit cell death. In this chapter, we briefly reviewed the various modes of mitochondrial Ca2+ uptake and our current understanding of mitochondrial Ca2+ homeostasis in regards to cell physiology and pathophysiology. Further, this chapter focuses on the molecular identities, intracellular regulators as well as the pharmacology of mitochondrial Ca2+ uniporter complex.
|Original language||English (US)|
|Title of host publication||Handbook of Experimental Pharmacology|
|Publisher||Springer New York LLC|
|State||Published - 2017|
|Name||Handbook of Experimental Pharmacology|
Bibliographical noteFunding Information:
This work was partly supported by National Heart, Lung, and Blood Institute Grants 2R01 HL-093671 and HL-114760 (to S. S. Sheu), 1R01 HL-122124 (to G. Csordas and S. S. Sheu). American Heart Association Grant 16SDG27260248 (to J. O-Uchi).
- Mitochondrial Ca uniporter
- Mitochondrial Ca uptake