The Minneapolis-Manchester quality of life instrument: Reliability and validity of the youth form

Smita Bhatia, Meriel E M Jenney, Eric Wu, Monica K. Bogue, Todd H. Rockwood, James H. Feusner, Debra L. Friedman, Leslie L. Robison, Robert L. Kane

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Objective Improvements in survival after childhood cancer have increased emphasis on health-related quality of life (HRQoL) of survivors. We developed the Minneapolis-Manchester Quality of Life-Youth Form (MMQL-YF) as a standardized patient self-report instrument designed to assess HRQoL in childhood cancer survivors between the ages of 8 and 12 years. Study design To validate the instrument, the MMQL-YF was administered to 643 children (481 healthy, 162 with cancer). Factor analysis was conducted to refine the instrument, and Cronbach's α coefficient was used to measure its internal reliability. Known-groups validity was determined by comparing healthy children with those with cancer. Construct validity was studied by a comparison of similar domains in the MMQL-YF and the Child Health Questionnaire (CHQ). Stability was tested by re-administration of the MMQL-YF 2 weeks later. Results Internal consistency reliability was in the acceptable range for this instrument. The MMQL-YF was able to distinguish between known groups, and its scales correlated highly with similar CHQ domains. Test-retest reliability showed that the instrument was extremely stable in all scales tested. Conclusion Data provide evidence for the validity and reliability of the MMQL-YF as a comprehensive, multidimensional, self-report instrument for measuring HRQoL among childhood cancer survivors.

Original languageEnglish (US)
Pages (from-to)39-46
Number of pages8
JournalJournal of Pediatrics
Issue number1
StatePublished - Jul 2004

Bibliographical note

Funding Information:
Supported in part by the Children's Oncology Group grant 1 U10 CA098543-01.


  • CHQ
  • Child Health Questionnaire
  • HRQoL
  • Health-related quality of life
  • Minneapolis-Manchester Quality of Life-Youth Form


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