The Microbiome and Chronic Rhinosinusitis

Do Yeon Cho; Ryan C. Hunter; Vijay R. Ramakrishnan

doi:10.1016/j.iac.2019.12.009

The Microbiome and Chronic Rhinosinusitis

Do Yeon Cho, Ryan C. Hunter, Vijay R. Ramakrishnan

Microbiology

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

Chronic rhinosinusitis (CRS) is persistent inflammation and/or infection of the nasal cavity and paranasal sinuses. Recent advancements in culture-independent molecular techniques have enhanced understanding of interactions between sinus microbiota and upper airway microenvironment. The dysbiosis hypothesis—alteration of microbiota associated with perturbation of the local ecological landscape—is suggested as a mechanism involved in CRS pathogenesis. This review discusses the complex role of the microbiota in health and in CRS and considerations in sinus microbiome investigation, dysbiosis of sinus microbiota in CRS, microbial interactions in CRS, and development of preclinical models. The authors conclude with future directions for CRS-associated microbiome research.

Original language	English (US)
Pages (from-to)	251-263
Number of pages	13
Journal	Immunology and Allergy Clinics of North America
Volume	40
Issue number	2
DOIs	https://doi.org/10.1016/j.iac.2019.12.009
State	Published - May 2020

Bibliographical note

Funding Information:
Research reported in this publication was supported by the National Institute on Deafness and Other Communication Disorders of the National Institutes of Health under award number K23DC014747 (V.R. Ramakrishnan), National Institute of Allergy and Infectious Diseases K08AI146220 (D-.Y. Cho), Flight Attendant Medical Research Institute grant CIA130066 (Daniel Frank and V.R. Ramakrishnan), American Rhinologic Society New Investigator Award (D-.Y. Cho), Cystic Fibrosis Foundation Research Development Pilot grant (ROWE15R0) (D-.Y. Cho), Cystic Fibrosis Foundation postdoctoral fellowship (FLYNN16F0), and National Center for Advancing Translational Sciences grant (UL1TR000114) to R.C. Hunter. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Funding Information:
Research reported in this publication was supported by the National Institute on Deafness and Other Communication Disorders of the National Institutes of Health under award number K23DC014747 (V.R. Ramakrishnan), National Institute of Allergy and Infectious Diseases K08AI146220 (D-.Y. Cho), Flight Attendant Medical Research Institute grant CIA130066 (Daniel Frank and V.R. Ramakrishnan), American Rhinologic Society New Investigator Award (D-.Y. Cho), Cystic Fibrosis Foundation Research Development Pilot grant ( ROWE15R0 ) (D-.Y. Cho), Cystic Fibrosis Foundation postdoctoral fellowship (FLYNN16F0), and National Center for Advancing Translational Sciences grant ( UL1TR000114 ) to R.C. Hunter. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Publisher Copyright:
© 2019 Elsevier Inc.

Keywords

Anaerobe
Animal model of CRS
Chronic rhinosinusitis
Microbiome
Mucin fermentation
Pseudomonas
Sinusitis

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title = "The Microbiome and Chronic Rhinosinusitis",

abstract = "Chronic rhinosinusitis (CRS) is persistent inflammation and/or infection of the nasal cavity and paranasal sinuses. Recent advancements in culture-independent molecular techniques have enhanced understanding of interactions between sinus microbiota and upper airway microenvironment. The dysbiosis hypothesis—alteration of microbiota associated with perturbation of the local ecological landscape—is suggested as a mechanism involved in CRS pathogenesis. This review discusses the complex role of the microbiota in health and in CRS and considerations in sinus microbiome investigation, dysbiosis of sinus microbiota in CRS, microbial interactions in CRS, and development of preclinical models. The authors conclude with future directions for CRS-associated microbiome research.",

keywords = "Anaerobe, Animal model of CRS, Chronic rhinosinusitis, Microbiome, Mucin fermentation, Pseudomonas, Sinusitis",

author = "Cho, {Do Yeon} and Hunter, {Ryan C.} and Ramakrishnan, {Vijay R.}",

note = "Funding Information: Research reported in this publication was supported by the National Institute on Deafness and Other Communication Disorders of the National Institutes of Health under award number K23DC014747 (V.R. Ramakrishnan), National Institute of Allergy and Infectious Diseases K08AI146220 (D-.Y. Cho), Flight Attendant Medical Research Institute grant CIA130066 (Daniel Frank and V.R. Ramakrishnan), American Rhinologic Society New Investigator Award (D-.Y. Cho), Cystic Fibrosis Foundation Research Development Pilot grant (ROWE15R0) (D-.Y. Cho), Cystic Fibrosis Foundation postdoctoral fellowship (FLYNN16F0), and National Center for Advancing Translational Sciences grant (UL1TR000114) to R.C. Hunter. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Funding Information: Research reported in this publication was supported by the National Institute on Deafness and Other Communication Disorders of the National Institutes of Health under award number K23DC014747 (V.R. Ramakrishnan), National Institute of Allergy and Infectious Diseases K08AI146220 (D-.Y. Cho), Flight Attendant Medical Research Institute grant CIA130066 (Daniel Frank and V.R. Ramakrishnan), American Rhinologic Society New Investigator Award (D-.Y. Cho), Cystic Fibrosis Foundation Research Development Pilot grant ( ROWE15R0 ) (D-.Y. Cho), Cystic Fibrosis Foundation postdoctoral fellowship (FLYNN16F0), and National Center for Advancing Translational Sciences grant ( UL1TR000114 ) to R.C. Hunter. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

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AB - Chronic rhinosinusitis (CRS) is persistent inflammation and/or infection of the nasal cavity and paranasal sinuses. Recent advancements in culture-independent molecular techniques have enhanced understanding of interactions between sinus microbiota and upper airway microenvironment. The dysbiosis hypothesis—alteration of microbiota associated with perturbation of the local ecological landscape—is suggested as a mechanism involved in CRS pathogenesis. This review discusses the complex role of the microbiota in health and in CRS and considerations in sinus microbiome investigation, dysbiosis of sinus microbiota in CRS, microbial interactions in CRS, and development of preclinical models. The authors conclude with future directions for CRS-associated microbiome research.

KW - Anaerobe

KW - Animal model of CRS

KW - Chronic rhinosinusitis

KW - Microbiome

KW - Mucin fermentation

KW - Pseudomonas

KW - Sinusitis

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JO - Immunology and Allergy Clinics of North America

JF - Immunology and Allergy Clinics of North America

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ER -

The Microbiome and Chronic Rhinosinusitis

Abstract

Bibliographical note

Keywords

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