The Microbiome and Chronic Rhinosinusitis

Do Yeon Cho, Ryan C. Hunter, Vijay R. Ramakrishnan

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Chronic rhinosinusitis (CRS) is persistent inflammation and/or infection of the nasal cavity and paranasal sinuses. Recent advancements in culture-independent molecular techniques have enhanced understanding of interactions between sinus microbiota and upper airway microenvironment. The dysbiosis hypothesis—alteration of microbiota associated with perturbation of the local ecological landscape—is suggested as a mechanism involved in CRS pathogenesis. This review discusses the complex role of the microbiota in health and in CRS and considerations in sinus microbiome investigation, dysbiosis of sinus microbiota in CRS, microbial interactions in CRS, and development of preclinical models. The authors conclude with future directions for CRS-associated microbiome research.

Original languageEnglish (US)
Pages (from-to)251-263
Number of pages13
JournalImmunology and Allergy Clinics of North America
Volume40
Issue number2
DOIs
StatePublished - May 2020

Bibliographical note

Funding Information:
Research reported in this publication was supported by the National Institute on Deafness and Other Communication Disorders of the National Institutes of Health under award number K23DC014747 (V.R. Ramakrishnan), National Institute of Allergy and Infectious Diseases K08AI146220 (D-.Y. Cho), Flight Attendant Medical Research Institute grant CIA130066 (Daniel Frank and V.R. Ramakrishnan), American Rhinologic Society New Investigator Award (D-.Y. Cho), Cystic Fibrosis Foundation Research Development Pilot grant (ROWE15R0) (D-.Y. Cho), Cystic Fibrosis Foundation postdoctoral fellowship (FLYNN16F0), and National Center for Advancing Translational Sciences grant (UL1TR000114) to R.C. Hunter. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Funding Information:
Research reported in this publication was supported by the National Institute on Deafness and Other Communication Disorders of the National Institutes of Health under award number K23DC014747 (V.R. Ramakrishnan), National Institute of Allergy and Infectious Diseases K08AI146220 (D-.Y. Cho), Flight Attendant Medical Research Institute grant CIA130066 (Daniel Frank and V.R. Ramakrishnan), American Rhinologic Society New Investigator Award (D-.Y. Cho), Cystic Fibrosis Foundation Research Development Pilot grant ( ROWE15R0 ) (D-.Y. Cho), Cystic Fibrosis Foundation postdoctoral fellowship (FLYNN16F0), and National Center for Advancing Translational Sciences grant ( UL1TR000114 ) to R.C. Hunter. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Publisher Copyright:
© 2019 Elsevier Inc.

Keywords

  • Anaerobe
  • Animal model of CRS
  • Chronic rhinosinusitis
  • Microbiome
  • Mucin fermentation
  • Pseudomonas
  • Sinusitis

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