The meninges enhance leukaemia survival in cerebral spinal fluid

Patrick Basile, Leslie M. Jonart, Maryam Ebadi, Kimberly Johnson, Morgan Kerfeld, Peter M. Gordon

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Central nervous system (CNS) relapse is a common cause of treatment failure in patients with acute lymphoblastic leukaemia (ALL) despite current CNS-directed therapies that are also associated with significant short- and long-term toxicities. Herein, we showed that leukaemia cells exhibit decreased proliferation, elevated reactive oxygen species (ROS) and increased cell death in cerebral spinal fluid (CSF) both in vitro and in vivo. However, interactions between leukaemia and meningeal cells mitigated these adverse effects. This work expands our understanding of the pathophysiology of CNS leukaemia and suggests novel therapeutic approaches for more effectively targeting leukaemia cells in the CNS.

Original languageEnglish (US)
Pages (from-to)513-517
Number of pages5
JournalBritish journal of haematology
Volume189
Issue number3
DOIs
StatePublished - May 1 2020

Keywords

  • acute lymphpoblastic leukaemia
  • cell adhesion
  • cell death
  • central nervous system
  • cerebral spinal fluid

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

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