The maternal immune activation (MIA) model of schizophrenia produces pre-pulse inhibition (PPI) deficits in both juvenile and adult rats but these effects are not associated with maternal weight loss

Amy R. Wolff, David K. Bilkey

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

The developmental onset of deficits in sensorimotor-gating was examined in the maternal immune activation (MIA) animal model of schizophrenia. Pre-pulse inhibition (PPI) deficits were evident in juvenile MIA rats. This parallels the sensorimotor-gating deficits observed in groups at high-risk of schizophrenia. PPI deficits were independent of maternal weight loss following the MIA manipulation, suggesting that this measure may not be a useful marker of treatment efficacy.

Original languageEnglish (US)
Pages (from-to)323-327
Number of pages5
JournalBehavioural Brain Research
Volume213
Issue number2
DOIs
StatePublished - Dec 1 2010
Externally publishedYes

Keywords

  • Juvenile
  • MIA
  • Maternal weight
  • Poly I:C
  • Pre-pulse inhibition
  • Schizophrenia
  • Sensorimotor-gating

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