The developmental onset of deficits in sensorimotor-gating was examined in the maternal immune activation (MIA) animal model of schizophrenia. Pre-pulse inhibition (PPI) deficits were evident in juvenile MIA rats. This parallels the sensorimotor-gating deficits observed in groups at high-risk of schizophrenia. PPI deficits were independent of maternal weight loss following the MIA manipulation, suggesting that this measure may not be a useful marker of treatment efficacy.
Bibliographical noteFunding Information:
This research was supported by a grant from the Health Research Council of New Zealand . We also thank S. Illingworth for her involvement.
- Maternal weight
- Poly I:C
- Pre-pulse inhibition