The maternal immune activation (MIA) model of schizophrenia produces pre-pulse inhibition (PPI) deficits in both juvenile and adult rats but these effects are not associated with maternal weight loss

Amy R. Wolff; David K. Bilkey

doi:10.1016/j.bbr.2010.05.008

The maternal immune activation (MIA) model of schizophrenia produces pre-pulse inhibition (PPI) deficits in both juvenile and adult rats but these effects are not associated with maternal weight loss

Amy R. Wolff, David K. Bilkey

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

The developmental onset of deficits in sensorimotor-gating was examined in the maternal immune activation (MIA) animal model of schizophrenia. Pre-pulse inhibition (PPI) deficits were evident in juvenile MIA rats. This parallels the sensorimotor-gating deficits observed in groups at high-risk of schizophrenia. PPI deficits were independent of maternal weight loss following the MIA manipulation, suggesting that this measure may not be a useful marker of treatment efficacy.

Original language	English (US)
Pages (from-to)	323-327
Number of pages	5
Journal	Behavioural Brain Research
Volume	213
Issue number	2
DOIs	https://doi.org/10.1016/j.bbr.2010.05.008
State	Published - Dec 2010
Externally published	Yes

Bibliographical note

Funding Information:
This research was supported by a grant from the Health Research Council of New Zealand . We also thank S. Illingworth for her involvement.

Keywords

Juvenile
MIA
Maternal weight
Poly I:C
Pre-pulse inhibition
Schizophrenia
Sensorimotor-gating

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10.1016/j.bbr.2010.05.008

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The maternal immune activation (MIA) model of schizophrenia produces pre-pulse inhibition (PPI) deficits in both juvenile and adult rats but these effects are not associated with maternal weight loss. / Wolff, Amy R.; Bilkey, David K.
In: Behavioural Brain Research, Vol. 213, No. 2, 12.2010, p. 323-327.

Research output: Contribution to journal › Article › peer-review

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The maternal immune activation (MIA) model of schizophrenia produces pre-pulse inhibition (PPI) deficits in both juvenile and adult rats but these effects are not associated with maternal weight loss

Abstract

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