The many roles of myosins in filopodia, microvilli and stereocilia

Anne Houdusse, Margaret A. Titus

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Filopodia, microvilli and stereocilia represent an important group of plasma membrane protrusions. These specialized projections are supported by parallel bundles of actin filaments and have critical roles in sensing the external environment, increasing cell surface area, and acting as mechanosensors. While actin-associated proteins are essential for actin-filament elongation and bundling in these protrusions, myosin motors have a surprising role in the formation and extension of filopodia and stereocilia and in the organization of microvilli. Actin regulators and specific myosins collaborate in controlling the length of these structures. Myosins can transport cargoes along the length of these protrusions, and, in the case of stereocilia and microvilli, interactions with adaptors and cargoes can also serve to anchor adhesion receptors to the actin-rich core via functionally conserved motor–adaptor complexes. This review highlights recent progress in understanding the diverse roles myosins play in filopodia, microvilli and stereocilia.

Original languageEnglish (US)
Pages (from-to)R586-R602
JournalCurrent Biology
Volume31
Issue number10
DOIs
StatePublished - May 24 2021

Bibliographical note

Funding Information:
A.H. is supported by an IRP grant from CNRS, ANR-17-CE11-0029-01, ANR-19-CE11-0015-02. The A.H. team is part of the Labex Cell(n)Scale (ANR-11-LABX-0038), which is part of the IDEX PSL (ANR-10-IDEX-0001-02). M.A.T. is supported by the NIH National Institute of General Medical Sciences (R01GM122917). The authors declare no competing interests.

Funding Information:
A.H. is supported by an IRP grant from CNRS, ANR-17-CE11-0029-01, ANR-19-CE11-0015-02. The A.H. team is part of the Labex Cell(n)Scale (ANR-11-LABX-0038), which is part of the IDEX PSL (ANR-10-IDEX-0001-02). M.A.T. is supported by the NIH National Institute of General Medical Sciences (R01GM122917).

Publisher Copyright:
© 2021 Elsevier Inc.

PubMed: MeSH publication types

  • Journal Article
  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

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