The macrocyclization reaction of terminal dibromoalkanes with sulfide on alumina. The use of a solid support as an alternative to the high dilution technique.

Lay Choo Tan, Richard M. Pagni, George W. Kabalka, Marc A Hillmyer, Julie Woosley

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

The reaction of a series of terminal dibromoalkanes with S-2 on Al2O3 has been examined. The use of a solid support for the macrocyclization represents a viable alternate procedure to the more traditional high dilution technique in solution. The cyclizations also occur with thioacetamide on unactivated alumina.

Original languageEnglish (US)
Pages (from-to)7709-7712
Number of pages4
JournalTetrahedron Letters
Volume33
Issue number50
DOIs
StatePublished - Dec 8 1993

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