The long (and winding) road to gene discovery for canine hip dysplasia

Lan Zhu, Zhiwu Zhang, Steven Friedenberg, Seung Woo Jung, Janjira Phavaphutanon, Margaret Vernier-Singer, Elizabeth Corey, Raluca Mateescu, Nathan Dykes, Jody Sandler, Gregory Acland, George Lust, Rory Todhunter

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations

Abstract

Hip dysplasia is a common inherited trait of dogs that results in secondary osteoarthritis. In this article the methods used to uncover the mutations contributing to this condition are reviewed, beginning with hip phenotyping. Coarse, genome-wide, microsatellite-based screens of pedigrees of greyhounds and dysplastic Labrador retrievers were used to identify linked quantitative trait loci (QTL). Fine-mapping across two chromosomes (CFA11 and 29) was employed using single nucleotide polymorphism (SNP) genotyping. Power analyses and preferential selection of dogs for ongoing SNP-based genotyping is described with the aim of refining the QTL intervals to 1-2 megabases on these and several additional chromosomes prior to candidate gene screening. The review considers how a mutation or a genetic marker such as a SNP or haplotype of SNPs might be combined with pedigree and phenotype information to create a 'breeding value' that could improve the accuracy of predicting a dog's hip conformation.

Original languageEnglish (US)
Pages (from-to)97-110
Number of pages14
JournalVeterinary Journal
Volume181
Issue number2
DOIs
StatePublished - Aug 1 2009

Keywords

  • Breeding values
  • Canine hip dysplasia
  • Genome wide screen
  • Microsatellites
  • Single nucleotide polymorphisms (SNP)

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