The little brain and the seahorse: Cerebellar-hippocampal interactions

Jessica M. Froula, Shayne D. Hastings, Esther Krook-Magnuson

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


There is a growing appreciation for the cerebellum beyond its role in motor function and accumulating evidence that the cerebellum and hippocampus interact across a range of brain states and behaviors. Acute and chronic manipulations, simultaneous recordings, and imaging studies together indicate coordinated coactivation and a bidirectional functional connectivity relevant for various physiological functions, including spatiotemporal processing. This bidirectional functional connectivity is likely supported by multiple circuit paths. It is also important in temporal lobe epilepsy: the cerebellum is impacted by seizures and epilepsy, and modulation of cerebellar circuitry can be an effective strategy to inhibit hippocampal seizures. This review highlights some of the recent key hippobellum literature.

Original languageEnglish (US)
Article number1158492
JournalFrontiers in Systems Neuroscience
StatePublished - 2023

Bibliographical note

Funding Information:
This work was supported by the National Institute of Health (RO1-NS112518 to EK-M), a University of Minnesota McKnight Presidential Fellowship (to EK-M), and a University of Minnesota MnDRIVE (Minnesota’s Discovery, Research and Innovation Economy) Neuromodulation Fellowship (to SH).

Publisher Copyright:
Copyright © 2023 Froula, Hastings and Krook-Magnuson.


  • coherence
  • fastigial
  • navigation
  • oscillations
  • place cells
  • social
  • supramammillary
  • vermis

PubMed: MeSH publication types

  • Journal Article
  • Review


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