The link between obesity and low circulating 25-hydroxyvitamin D concentrations: Considerations and implications

Carrie P Earthman, L. M. Beckman, K. Masodkar, Shalamar Sibley

Research output: Contribution to journalReview article

238 Citations (Scopus)

Abstract

Obesity and vitamin D deficiency have both been recognized as major public health issues worldwide, and there is growing evidence that they are related, although the cause-effect relationship remains unclear. Could obesity be contributing to low circulating 25-hydroxyvitamin D concentrations? Alternatively, could low vitamin D status predispose to obesity? In this review, the relationship between low circulating 25-hydroxyvitamin D and obesity, and possible underlying reasons from both perspectives, is presented. One potential mechanism by which obesity could contribute to low serum 25-hydroxyvitamin D is adipose sequestration of vitamin D. On the other hand, adipose tissue has both the vitamin D receptor and the ability to synthesize 1,25-dihydroxyvitamin D, and there is evidence that vitamin D may regulate adipose tissue mass, differentiation and metabolism in ways that might contribute to obesity. Of particular interest, vitamin D deficiency is common both before and after bariatric surgery, and is often difficult to treat, particularly with the more malabsorptive procedures. Additional research is needed to elucidate the complex and multifaceted factors underlying the association between low circulating 25-hydroxyvitamin D and obesity, and to identify optimal treatment approaches in obese individuals and in bariatric surgical patients both before and after surgery.

Original languageEnglish (US)
Pages (from-to)387-396
Number of pages10
JournalInternational Journal of Obesity
Volume36
Issue number3
DOIs
StatePublished - Mar 1 2012

Fingerprint

Obesity
Vitamin D
Vitamin D Deficiency
Adipose Tissue
Bariatrics
Calcitriol Receptors
Bariatric Surgery
25-hydroxyvitamin D
Public Health
Serum
Research

Keywords

  • adipose
  • deficiency
  • inadequacy
  • insufficiency
  • vitamin D

Cite this

The link between obesity and low circulating 25-hydroxyvitamin D concentrations : Considerations and implications. / Earthman, Carrie P; Beckman, L. M.; Masodkar, K.; Sibley, Shalamar.

In: International Journal of Obesity, Vol. 36, No. 3, 01.03.2012, p. 387-396.

Research output: Contribution to journalReview article

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