The link between ancient microbial fluoride resistance mechanisms and bioengineering organofluorine degradation or synthesis

Randy B. Stockbridge, Lawrence P. Wackett

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Fluorinated organic chemicals, such as per- and polyfluorinated alkyl substances (PFAS) and fluorinated pesticides, are both broadly useful and unusually long-lived. To combat problems related to the accumulation of these compounds, microbial PFAS and organofluorine degradation and biosynthesis of less-fluorinated replacement chemicals are under intense study. Both efforts are undermined by the substantial toxicity of fluoride, an anion that powerfully inhibits metabolism. Microorganisms have contended with environmental mineral fluoride over evolutionary time, evolving a suite of detoxification mechanisms. In this perspective, we synthesize emerging ideas on microbial defluorination/fluorination and fluoride resistance mechanisms and identify best approaches for bioengineering new approaches for degrading and making organofluorine compounds.

Original languageEnglish (US)
Article number4593
JournalNature communications
Volume15
Issue number1
DOIs
StatePublished - Dec 2024

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© The Author(s) 2024.

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