This commentary to the capstone paper by Keshavan and colleagues reflects on the history of this project and the challenging nature of curating and establishing facts. While a number of approaches exist, none of them in-and-of-themselves are without drawbacks. A combination of techniques may provide the most satisfying results. We emphasize the importance of determining what facts are specific to the disorder - a particularly challenging endeavor - and the usefulness of various ways of quantifying these facts.
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