The landmark JDRF continuous glucose monitoring randomized trials: A look back at the accumulated evidence

William V. Tamborlane; Roy W. Beck; Lori Laffel; Katrina J. Ruedy; H. Peter Chase; Rosanna Fiallo-Scharer; Laurel Messer; Victoria Gage; Patricia Burdick; Kerry Milaszewski; Katherine Pratt; Elise Bismuth; Joyce Keady; Margie Lawlor; Bruce Buckingham; Darrell M. Wilson; Jennifer Block; Kari Benassi; Eva Tsalikian; Michael Tansey; Debra Kucera; Julie Coffey; Joanne Cabbage; Howard Wolpert; Greeshma Shetty; Astrid Atakov-Castillo; Judith Giusti; Stacey O'Donnell; Suzanne Ghiloni; Irl B. Hirsch; Lisa K. Gilliam; Kathy Fitzpatrick; Dori Khakpour; Tim Wysocki; Larry A. Fox; Nelly Mauras; Kimberly Englert; Joe Permuy; Bruce W. Bode; Kelli O'Neil; Lisa Tolbert; Jean M. Lawrence; Robert Clemons; Michelle Maeva; Bonnie Sattler; Stuart Weinzimer; Brett Ives; Joan Bosson-Heenan; Craig Kollman; Dongyuan Xing; Judy Jackson; Michael Steffes; Jean M. Bucksa; Maren L. Nowicki; Carol Van Hale; Vicky Makky; Michael O'Grady; Elbert Huang; Anirban Basu; David O. Meltzer; Lan Zhao; Joyce Lee; Aaron J. Kowalski; Ruth S. Weinstock; Barbara J. Anderson; Davida Kruger; Lisa LaVange; Henry Rodriguez

doi:10.1007/s12265-012-9364-9

The landmark JDRF continuous glucose monitoring randomized trials: A look back at the accumulated evidence

William V. Tamborlane, Roy W. Beck, Lori Laffel, Katrina J. Ruedy, H. Peter Chase, Rosanna Fiallo-Scharer, Laurel Messer, Victoria Gage, Patricia Burdick, Kerry Milaszewski, Katherine Pratt, Elise Bismuth, Joyce Keady, Margie Lawlor, Bruce Buckingham, Darrell M. Wilson, Jennifer Block, Kari Benassi, Eva Tsalikian, Michael TanseyDebra Kucera, Julie Coffey, Joanne Cabbage, Howard Wolpert, Greeshma Shetty, Astrid Atakov-Castillo, Judith Giusti, Stacey O'Donnell, Suzanne Ghiloni, Irl B. Hirsch, Lisa K. Gilliam, Kathy Fitzpatrick, Dori Khakpour, Tim Wysocki, Larry A. Fox, Nelly Mauras, Kimberly Englert, Joe Permuy, Bruce W. Bode, Kelli O'Neil, Lisa Tolbert, Jean M. Lawrence, Robert Clemons, Michelle Maeva, Bonnie Sattler, Stuart Weinzimer, Brett Ives, Joan Bosson-Heenan, Craig Kollman, Dongyuan Xing, Judy Jackson, Michael Steffes, Jean M. Bucksa, Maren L. Nowicki, Carol Van Hale, Vicky Makky, Michael O'Grady, Elbert Huang, Anirban Basu, David O. Meltzer, Lan Zhao, Joyce Lee, Aaron J. Kowalski, Ruth S. Weinstock, Barbara J. Anderson, Davida Kruger, Lisa LaVange, Henry Rodriguez

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Despite improvements for management of type 1 diabetes (T1D), patients have difficulty achieving glycated hemoglobin (A1c) levels recommended by the Diabetes Control and Complications Trial (DCCT). Two multicenter randomized trials were conducted to evaluate benefit of using a continuous glucose monitor (CGM) with standard glucose monitoring for T1D management. The primary study evaluated benefits of CGM in 322 patients with A1c >7.0 %. The secondary study evaluated 129 patients with A1c <7.0 %. In the primary study, CGM resulted in improvements in A1c at 6 m in subjects >25 years, but not those <25. However, all subjects using CGM regularly showed benefit. Improved A1c did not come with increased severe hypoglycemia as seen in the DCCT, and benefit was sustained over 1 year. In the secondary study, CGM use helped subjects maintain target A1c levels with reduced exposure to biochemical hypoglycemia. The data collected allowed for other analyses of important factors in T1D management.

Original language	English (US)
Pages (from-to)	380-387
Number of pages	8
Journal	Journal of cardiovascular translational research
Volume	5
Issue number	4
DOIs	https://doi.org/10.1007/s12265-012-9364-9
State	Published - Aug 2012

Keywords

Continuous glucose monitoring
Glycated hemoglobin
Hypoglycemia
Psychosocial factors
Type 1 diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12265-012-9364-9

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Tamborlane, W. V., Beck, R. W., Laffel, L., Ruedy, K. J., Chase, H. P., Fiallo-Scharer, R., Messer, L., Gage, V., Burdick, P., Milaszewski, K., Pratt, K., Bismuth, E., Keady, J., Lawlor, M., Buckingham, B., Wilson, D. M., Block, J., Benassi, K., Tsalikian, E., ... Rodriguez, H. (2012). The landmark JDRF continuous glucose monitoring randomized trials: A look back at the accumulated evidence. Journal of cardiovascular translational research, 5(4), 380-387. https://doi.org/10.1007/s12265-012-9364-9

Tamborlane, WV, Beck, RW, Laffel, L, Ruedy, KJ, Chase, HP, Fiallo-Scharer, R, Messer, L, Gage, V, Burdick, P, Milaszewski, K, Pratt, K, Bismuth, E, Keady, J, Lawlor, M, Buckingham, B, Wilson, DM, Block, J, Benassi, K, Tsalikian, E, Tansey, M, Kucera, D, Coffey, J, Cabbage, J, Wolpert, H, Shetty, G, Atakov-Castillo, A, Giusti, J, O'Donnell, S, Ghiloni, S, Hirsch, IB, Gilliam, LK, Fitzpatrick, K, Khakpour, D, Wysocki, T, Fox, LA, Mauras, N, Englert, K, Permuy, J, Bode, BW, O'Neil, K, Tolbert, L, Lawrence, JM, Clemons, R, Maeva, M, Sattler, B, Weinzimer, S, Ives, B, Bosson-Heenan, J, Kollman, C, Xing, D, Jackson, J, Steffes, M, Bucksa, JM, Nowicki, ML, Van Hale, C, Makky, V, O'Grady, M, Huang, E, Basu, A, Meltzer, DO, Zhao, L, Lee, J, Kowalski, AJ, Weinstock, RS, Anderson, BJ, Kruger, D, LaVange, L & Rodriguez, H 2012, 'The landmark JDRF continuous glucose monitoring randomized trials: A look back at the accumulated evidence', Journal of cardiovascular translational research, vol. 5, no. 4, pp. 380-387. https://doi.org/10.1007/s12265-012-9364-9

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title = "The landmark JDRF continuous glucose monitoring randomized trials: A look back at the accumulated evidence",

abstract = "Despite improvements for management of type 1 diabetes (T1D), patients have difficulty achieving glycated hemoglobin (A1c) levels recommended by the Diabetes Control and Complications Trial (DCCT). Two multicenter randomized trials were conducted to evaluate benefit of using a continuous glucose monitor (CGM) with standard glucose monitoring for T1D management. The primary study evaluated benefits of CGM in 322 patients with A1c >7.0 \%. The secondary study evaluated 129 patients with A1c <7.0 \%. In the primary study, CGM resulted in improvements in A1c at 6 m in subjects >25 years, but not those <25. However, all subjects using CGM regularly showed benefit. Improved A1c did not come with increased severe hypoglycemia as seen in the DCCT, and benefit was sustained over 1 year. In the secondary study, CGM use helped subjects maintain target A1c levels with reduced exposure to biochemical hypoglycemia. The data collected allowed for other analyses of important factors in T1D management.",

keywords = "Continuous glucose monitoring, Glycated hemoglobin, Hypoglycemia, Psychosocial factors, Type 1 diabetes",

author = "Tamborlane, \{William V.\} and Beck, \{Roy W.\} and Lori Laffel and Ruedy, \{Katrina J.\} and Chase, \{H. Peter\} and Rosanna Fiallo-Scharer and Laurel Messer and Victoria Gage and Patricia Burdick and Kerry Milaszewski and Katherine Pratt and Elise Bismuth and Joyce Keady and Margie Lawlor and Bruce Buckingham and Wilson, \{Darrell M.\} and Jennifer Block and Kari Benassi and Eva Tsalikian and Michael Tansey and Debra Kucera and Julie Coffey and Joanne Cabbage and Howard Wolpert and Greeshma Shetty and Astrid Atakov-Castillo and Judith Giusti and Stacey O'Donnell and Suzanne Ghiloni and Hirsch, \{Irl B.\} and Gilliam, \{Lisa K.\} and Kathy Fitzpatrick and Dori Khakpour and Tim Wysocki and Fox, \{Larry A.\} and Nelly Mauras and Kimberly Englert and Joe Permuy and Bode, \{Bruce W.\} and Kelli O'Neil and Lisa Tolbert and Lawrence, \{Jean M.\} and Robert Clemons and Michelle Maeva and Bonnie Sattler and Stuart Weinzimer and Brett Ives and Joan Bosson-Heenan and Craig Kollman and Dongyuan Xing and Judy Jackson and Michael Steffes and Bucksa, \{Jean M.\} and Nowicki, \{Maren L.\} and \{Van Hale\}, Carol and Vicky Makky and Michael O'Grady and Elbert Huang and Anirban Basu and Meltzer, \{David O.\} and Lan Zhao and Joyce Lee and Kowalski, \{Aaron J.\} and Weinstock, \{Ruth S.\} and Anderson, \{Barbara J.\} and Davida Kruger and Lisa LaVange and Henry Rodriguez",

year = "2012",

month = aug,

doi = "10.1007/s12265-012-9364-9",

language = "English (US)",

volume = "5",

pages = "380--387",

journal = "Journal of cardiovascular translational research",

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publisher = "Springer",

number = "4",

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T1 - The landmark JDRF continuous glucose monitoring randomized trials

T2 - A look back at the accumulated evidence

AU - Tamborlane, William V.

AU - Beck, Roy W.

AU - Laffel, Lori

AU - Ruedy, Katrina J.

AU - Chase, H. Peter

AU - Fiallo-Scharer, Rosanna

AU - Messer, Laurel

AU - Gage, Victoria

AU - Burdick, Patricia

AU - Milaszewski, Kerry

AU - Pratt, Katherine

AU - Bismuth, Elise

AU - Keady, Joyce

AU - Lawlor, Margie

AU - Buckingham, Bruce

AU - Wilson, Darrell M.

AU - Block, Jennifer

AU - Benassi, Kari

AU - Tsalikian, Eva

AU - Tansey, Michael

AU - Kucera, Debra

AU - Coffey, Julie

AU - Cabbage, Joanne

AU - Wolpert, Howard

AU - Shetty, Greeshma

AU - Atakov-Castillo, Astrid

AU - Giusti, Judith

AU - O'Donnell, Stacey

AU - Ghiloni, Suzanne

AU - Hirsch, Irl B.

AU - Gilliam, Lisa K.

AU - Fitzpatrick, Kathy

AU - Khakpour, Dori

AU - Wysocki, Tim

AU - Fox, Larry A.

AU - Mauras, Nelly

AU - Englert, Kimberly

AU - Permuy, Joe

AU - Bode, Bruce W.

AU - O'Neil, Kelli

AU - Tolbert, Lisa

AU - Lawrence, Jean M.

AU - Clemons, Robert

AU - Maeva, Michelle

AU - Sattler, Bonnie

AU - Weinzimer, Stuart

AU - Ives, Brett

AU - Bosson-Heenan, Joan

AU - Kollman, Craig

AU - Xing, Dongyuan

AU - Jackson, Judy

AU - Steffes, Michael

AU - Bucksa, Jean M.

AU - Nowicki, Maren L.

AU - Van Hale, Carol

AU - Makky, Vicky

AU - O'Grady, Michael

AU - Huang, Elbert

AU - Basu, Anirban

AU - Meltzer, David O.

AU - Zhao, Lan

AU - Lee, Joyce

AU - Kowalski, Aaron J.

AU - Weinstock, Ruth S.

AU - Anderson, Barbara J.

AU - Kruger, Davida

AU - LaVange, Lisa

AU - Rodriguez, Henry

PY - 2012/8

Y1 - 2012/8

N2 - Despite improvements for management of type 1 diabetes (T1D), patients have difficulty achieving glycated hemoglobin (A1c) levels recommended by the Diabetes Control and Complications Trial (DCCT). Two multicenter randomized trials were conducted to evaluate benefit of using a continuous glucose monitor (CGM) with standard glucose monitoring for T1D management. The primary study evaluated benefits of CGM in 322 patients with A1c >7.0 %. The secondary study evaluated 129 patients with A1c <7.0 %. In the primary study, CGM resulted in improvements in A1c at 6 m in subjects >25 years, but not those <25. However, all subjects using CGM regularly showed benefit. Improved A1c did not come with increased severe hypoglycemia as seen in the DCCT, and benefit was sustained over 1 year. In the secondary study, CGM use helped subjects maintain target A1c levels with reduced exposure to biochemical hypoglycemia. The data collected allowed for other analyses of important factors in T1D management.

AB - Despite improvements for management of type 1 diabetes (T1D), patients have difficulty achieving glycated hemoglobin (A1c) levels recommended by the Diabetes Control and Complications Trial (DCCT). Two multicenter randomized trials were conducted to evaluate benefit of using a continuous glucose monitor (CGM) with standard glucose monitoring for T1D management. The primary study evaluated benefits of CGM in 322 patients with A1c >7.0 %. The secondary study evaluated 129 patients with A1c <7.0 %. In the primary study, CGM resulted in improvements in A1c at 6 m in subjects >25 years, but not those <25. However, all subjects using CGM regularly showed benefit. Improved A1c did not come with increased severe hypoglycemia as seen in the DCCT, and benefit was sustained over 1 year. In the secondary study, CGM use helped subjects maintain target A1c levels with reduced exposure to biochemical hypoglycemia. The data collected allowed for other analyses of important factors in T1D management.

KW - Continuous glucose monitoring

KW - Glycated hemoglobin

KW - Hypoglycemia

KW - Psychosocial factors

KW - Type 1 diabetes

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U2 - 10.1007/s12265-012-9364-9

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M3 - Article

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SN - 1937-5387

VL - 5

SP - 380

EP - 387

JO - Journal of cardiovascular translational research

JF - Journal of cardiovascular translational research

IS - 4

ER -

The landmark JDRF continuous glucose monitoring randomized trials: A look back at the accumulated evidence

Abstract

Keywords

UN SDGs

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