The kinetics of penicillin diffusion in serum and middle ear effusions in experimentally induced otitis media

Steven S Juhn; J. Edlin; T. T.K. Jung; G. S. Giebink

doi:10.1007/BF00470617

The kinetics of penicillin diffusion in serum and middle ear effusions in experimentally induced otitis media

Steven S Juhn, J. Edlin, T. T.K. Jung, G. S. Giebink

Otolaryngology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The kinetics of penicillin diffusion in serum and middle ear effusions (MEE) was studied in experimentally induced serous otitis media (SOM) and purulent otitis media (POM) after systemic injection of procaine-penicillin G. A higher rate of diffusion of penicillin into the middle ear cavity was found in POM than in SOM. The time to reach peak concentrations in MEE was also shorter in POM. Elimination of penicillin from the middle ear cavity was slower in SOM than in POM.

Original language	English (US)
Pages (from-to)	183-185
Number of pages	3
Journal	Archives of Oto-Rhino-Laryngology
Volume	243
Issue number	3
DOIs	https://doi.org/10.1007/BF00470617
State	Published - May 1986

Keywords

Kinetics
Middle ear effusion
Penicillin
Serum

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10.1007/BF00470617

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abstract = "The kinetics of penicillin diffusion in serum and middle ear effusions (MEE) was studied in experimentally induced serous otitis media (SOM) and purulent otitis media (POM) after systemic injection of procaine-penicillin G. A higher rate of diffusion of penicillin into the middle ear cavity was found in POM than in SOM. The time to reach peak concentrations in MEE was also shorter in POM. Elimination of penicillin from the middle ear cavity was slower in SOM than in POM.",

keywords = "Kinetics, Middle ear effusion, Penicillin, Serum",

author = "Juhn, {Steven S} and J. Edlin and Jung, {T. T.K.} and Giebink, {G. S.}",

year = "1986",

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doi = "10.1007/BF00470617",

language = "English (US)",

volume = "243",

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AU - Juhn, Steven S

AU - Edlin, J.

AU - Jung, T. T.K.

AU - Giebink, G. S.

PY - 1986/5

Y1 - 1986/5

N2 - The kinetics of penicillin diffusion in serum and middle ear effusions (MEE) was studied in experimentally induced serous otitis media (SOM) and purulent otitis media (POM) after systemic injection of procaine-penicillin G. A higher rate of diffusion of penicillin into the middle ear cavity was found in POM than in SOM. The time to reach peak concentrations in MEE was also shorter in POM. Elimination of penicillin from the middle ear cavity was slower in SOM than in POM.

AB - The kinetics of penicillin diffusion in serum and middle ear effusions (MEE) was studied in experimentally induced serous otitis media (SOM) and purulent otitis media (POM) after systemic injection of procaine-penicillin G. A higher rate of diffusion of penicillin into the middle ear cavity was found in POM than in SOM. The time to reach peak concentrations in MEE was also shorter in POM. Elimination of penicillin from the middle ear cavity was slower in SOM than in POM.

KW - Kinetics

KW - Middle ear effusion

KW - Penicillin

KW - Serum

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ER -

The kinetics of penicillin diffusion in serum and middle ear effusions in experimentally induced otitis media

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