The kappa opioid receptor, ingestive behaviors and the obese mouse (ob/ob)

J. E. Morley; A. S. Levine; B. A. Gosnell; J. Kneip; M. Grace

The kappa opioid receptor, ingestive behaviors and the obese mouse (ob/ob)

J. E. Morley, A. S. Levine, B. A. Gosnell, J. Kneip, M. Grace

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23 Scopus citations

Abstract

Recent studies have suggested a role for the kappa opiate receptor and its endogenous ligand, dynorphin, in the central regulation of appetite. In this study we found that the ob/ob mouse was mildly resistant to the ability of three kappa agonists, viz. butorphanol, tifluadom, and ketocyclazocine to induce food intake. In addition, we could find no change in ir-dynorphin levels in 7 areas for the central nervous system. These findings do not provide evidence for a role of kappa opioid feeding system in the pathogenesis of obesity in the ob/ob mouse.

Original language	English (US)
Pages (from-to)	603-606
Number of pages	4
Journal	Physiology and Behavior
Volume	31
Issue number	5
State	Published - Dec 1 1983

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AU - Kneip, J.

AU - Grace, M.

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N2 - Recent studies have suggested a role for the kappa opiate receptor and its endogenous ligand, dynorphin, in the central regulation of appetite. In this study we found that the ob/ob mouse was mildly resistant to the ability of three kappa agonists, viz. butorphanol, tifluadom, and ketocyclazocine to induce food intake. In addition, we could find no change in ir-dynorphin levels in 7 areas for the central nervous system. These findings do not provide evidence for a role of kappa opioid feeding system in the pathogenesis of obesity in the ob/ob mouse.

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