The kappa opioid receptor, ingestive behaviors and the obese mouse (ob/ob)

J. E. Morley, A. S. Levine, B. A. Gosnell, J. Kneip, M. Grace

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Recent studies have suggested a role for the kappa opiate receptor and its endogenous ligand, dynorphin, in the central regulation of appetite. In this study we found that the ob/ob mouse was mildly resistant to the ability of three kappa agonists, viz. butorphanol, tifluadom, and ketocyclazocine to induce food intake. In addition, we could find no change in ir-dynorphin levels in 7 areas for the central nervous system. These findings do not provide evidence for a role of kappa opioid feeding system in the pathogenesis of obesity in the ob/ob mouse.

Original languageEnglish (US)
Pages (from-to)603-606
Number of pages4
JournalPhysiology and Behavior
Volume31
Issue number5
StatePublished - Dec 1 1983

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