The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor contains an immunoreceptor tyrosine-based inhibitory motif that activates Shp2

Nicola Philpott; Thomas Bakken; Christopher Pennell; Liwei Chen; Jie Wu; Mark Cannon

doi:10.1128/JVI.01362-10

The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor contains an immunoreceptor tyrosine-based inhibitory motif that activates Shp2

Nicola Philpott, Thomas Bakken, Christopher Pennell, Liwei Chen, Jie Wu, Mark Cannon

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The Kaposi's sarcoma-associated herpesvirus (KSHV) G protein-coupled receptor (vGPCR) is a constitutively active, highly angiogenic homologue of the interleukin-8 (IL-8) receptors that signals in part via the cytoplasmic protein tyrosine phosphatase Shp2. We show that vGPCR contains a bona fide immunoreceptor tyrosine-based inhibitory motif (ITIM) that binds and constitutively activates Shp2.

Original language	English (US)
Pages (from-to)	1140-1144
Number of pages	5
Journal	Journal of virology
Volume	85
Issue number	2
DOIs	https://doi.org/10.1128/JVI.01362-10
State	Published - Jan 2011
Externally published	Yes

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abstract = "The Kaposi's sarcoma-associated herpesvirus (KSHV) G protein-coupled receptor (vGPCR) is a constitutively active, highly angiogenic homologue of the interleukin-8 (IL-8) receptors that signals in part via the cytoplasmic protein tyrosine phosphatase Shp2. We show that vGPCR contains a bona fide immunoreceptor tyrosine-based inhibitory motif (ITIM) that binds and constitutively activates Shp2.",

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AU - Philpott, Nicola

AU - Bakken, Thomas

AU - Pennell, Christopher

AU - Chen, Liwei

AU - Wu, Jie

AU - Cannon, Mark

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AB - The Kaposi's sarcoma-associated herpesvirus (KSHV) G protein-coupled receptor (vGPCR) is a constitutively active, highly angiogenic homologue of the interleukin-8 (IL-8) receptors that signals in part via the cytoplasmic protein tyrosine phosphatase Shp2. We show that vGPCR contains a bona fide immunoreceptor tyrosine-based inhibitory motif (ITIM) that binds and constitutively activates Shp2.

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The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor contains an immunoreceptor tyrosine-based inhibitory motif that activates Shp2

Abstract

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