The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor contains an immunoreceptor tyrosine-based inhibitory motif that activates Shp2

Nicola Philpott, Thomas Bakken, Christopher Pennell, Liwei Chen, Jie Wu, Mark Cannon

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The Kaposi's sarcoma-associated herpesvirus (KSHV) G protein-coupled receptor (vGPCR) is a constitutively active, highly angiogenic homologue of the interleukin-8 (IL-8) receptors that signals in part via the cytoplasmic protein tyrosine phosphatase Shp2. We show that vGPCR contains a bona fide immunoreceptor tyrosine-based inhibitory motif (ITIM) that binds and constitutively activates Shp2.

Original languageEnglish (US)
Pages (from-to)1140-1144
Number of pages5
JournalJournal of virology
Volume85
Issue number2
DOIs
StatePublished - Jan 2011

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