The isolation and partial characterization of a protective antigen from developing larvae of Ascaris suum

Bert E. Stromberg

Research output: Contribution to journalArticle

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Abstract

An antigen (ACF antigen) obtained by in vitro cultivation of third-stage larvae of Ascaris suum to the fourth stage in defined medium induced significant protection in guinea pigs. The antigen was further characterized by ultrafiltration and gel filtration and was shown to be a single component by gel precipition and immunoelectrophoresis. It induced active cutaneous anaphylaxis in sensitized animals. The ACF antigen is estimated to contain about 79% protein and 22% carbohydrate and to have a molecular weight of approx 67,000.

Original languageEnglish (US)
Pages (from-to)307-311
Number of pages5
JournalInternational Journal for Parasitology
Volume9
Issue number4
DOIs
StatePublished - Aug 1979

Keywords

  • Ascaris suum
  • excretory-secretory product
  • functional antigen
  • protective immunity
  • soluble antigens
  • vaccination

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