The inverse association between a fish consumption biomarker and gingival inflammation and periodontitis: A population-based study

Filip Ottosson; Lina Hultgren; Celine Fernandez; Gunnar Engström; Marju Orho-Melander; Cecilia Kennbäck; Margaretha Persson; Ryan T. Demmer; Olle Melander; Björn Klinge; Peter M. Nilsson; Daniel Jönsson

doi:10.1111/jcpe.13602

The inverse association between a fish consumption biomarker and gingival inflammation and periodontitis: A population-based study

Filip Ottosson, Lina Hultgren, Celine Fernandez, Gunnar Engström, Marju Orho-Melander, Cecilia Kennbäck, Margaretha Persson, Ryan T. Demmer, Olle Melander, Björn Klinge, Peter M. Nilsson, Daniel Jönsson

Epidemiology & Community Health

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Aim: The metabolite 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid (CMPF) is a fatty fish–intake biomarker. We investigated the association between plasma levels of CMPF in relation to gingival inflammation and periodontitis case definition, as well as the extent and severity variables. Materials and Methods: The Malmö Offspring Study is a population-based study, and the Malmö Offspring Dental Study (MODS) is its dental arm, including periodontal charting. Plasma CMPF was measured using liquid chromatography–mass spectrometry and studied in relation to periodontal diagnosis and parameters using multivariable linear or logistic regression modelling adjusting for age, sex, education, body mass index, fasting glucose, and smoking. Results: Metabolite data were available for 922 MODS participants. Higher CMPF levels were associated with less gingival inflammation (β = −2.12, p =.002) and lower odds of severe periodontitis (odds ratio [OR] = 0.74, 95% confidence interval [CI]: 0.56 to 0.98). Higher CMPF levels were also associated with more teeth (β = 0.19, p =.001), lower number of periodontal pockets (≥4 mm) (β = −1.07, p =.007), and lower odds of having two or more periodontal pockets of ≥6 mm (OR = 0.80, 95% CI: 0.65 to 0.98) in fully adjusted models. Conclusions: CMPF, a validated biomarker of fatty fish consumption, is associated with less periodontal inflammation and periodontitis. Residual confounding cannot be ruled out, and future studies are warranted.

Original language	English (US)
Pages (from-to)	353-361
Number of pages	9
Journal	Journal of clinical periodontology
Volume	49
Issue number	4
DOIs	https://doi.org/10.1111/jcpe.13602
State	Published - Apr 2022

Bibliographical note

Funding Information:
Malmö Offspring Dental Study (MODS) was supported by grants from Oral Health Related Research by Region Skåne, the Crafoord Foundation, the Albert Påhlsson Foundation, and the Public Dental Service of Skåne. Malmö Offspring Study (MOS) was supported by the Research Council of Sweden, the Heart and Lung Foundation, and the Region Skåne County Council (ALF) grant. The authors would like to extend their gratitude to the following people working within the MODS study: the dentists, who examined the participants, (Liselott Bennvid, Elisabeth Hansson, Demir Cirgic, and Elisabeth Larsson) and biomedical scientists and nurses (Johanna Karlsson, Anna Hallberg, Christina Neroth, Anders Holm, and Ingegärd Lundgren Svensson). We are also profoundly grateful to the MOS/MODS participants for their participation in this research.

Funding Information:
Malmö Offspring Dental Study (MODS) was supported by grants from Oral Health Related Research by Region Skåne, the Crafoord Foundation, the Albert Påhlsson Foundation, and the Public Dental Service of Skåne. Malmö Offspring Study (MOS) was supported by the Research Council of Sweden, the Heart and Lung Foundation, and the Region Skåne County Council (ALF) grant. The authors would like to extend their gratitude to the following people working within the MODS study: the dentists, who examined the participants, (Liselott Bennvid, Elisabeth Hansson, Demir Cirgic, and Elisabeth Larsson) and biomedical scientists and nurses (Johanna Karlsson, Anna Hallberg, Christina Neroth, Anders Holm, and Ingegärd Lundgren Svensson). We are also profoundly grateful to the MOS/MODS participants for their participation in this research.

Publisher Copyright:
© 2022 The Authors. Journal of Clinical Periodontology published by John Wiley & Sons Ltd.

Keywords

CMPF
fish diet
gingival inflammation
metabolomics
periodontitis
Humans
Periodontitis/diagnosis
Inflammation
Periodontal Pocket
Gingivitis
Multiple Organ Failure
Animals
Biomarkers

PubMed: MeSH publication types

Research Support, Non-U.S. Gov't
Journal Article

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10.1111/jcpe.13602

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Ottosson, F., Hultgren, L., Fernandez, C., Engström, G., Orho-Melander, M., Kennbäck, C., Persson, M., Demmer, R. T., Melander, O., Klinge, B., Nilsson, P. M., & Jönsson, D. (2022). The inverse association between a fish consumption biomarker and gingival inflammation and periodontitis: A population-based study. Journal of clinical periodontology, 49(4), 353-361. https://doi.org/10.1111/jcpe.13602

Ottosson, F, Hultgren, L, Fernandez, C, Engström, G, Orho-Melander, M, Kennbäck, C, Persson, M, Demmer, RT, Melander, O, Klinge, B, Nilsson, PM & Jönsson, D 2022, 'The inverse association between a fish consumption biomarker and gingival inflammation and periodontitis: A population-based study', Journal of clinical periodontology, vol. 49, no. 4, pp. 353-361. https://doi.org/10.1111/jcpe.13602

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title = "The inverse association between a fish consumption biomarker and gingival inflammation and periodontitis: A population-based study",

abstract = "Aim: The metabolite 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid (CMPF) is a fatty fish–intake biomarker. We investigated the association between plasma levels of CMPF in relation to gingival inflammation and periodontitis case definition, as well as the extent and severity variables. Materials and Methods: The Malm{\"o} Offspring Study is a population-based study, and the Malm{\"o} Offspring Dental Study (MODS) is its dental arm, including periodontal charting. Plasma CMPF was measured using liquid chromatography–mass spectrometry and studied in relation to periodontal diagnosis and parameters using multivariable linear or logistic regression modelling adjusting for age, sex, education, body mass index, fasting glucose, and smoking. Results: Metabolite data were available for 922 MODS participants. Higher CMPF levels were associated with less gingival inflammation (β = −2.12, p =.002) and lower odds of severe periodontitis (odds ratio [OR] = 0.74, 95% confidence interval [CI]: 0.56 to 0.98). Higher CMPF levels were also associated with more teeth (β = 0.19, p =.001), lower number of periodontal pockets (≥4 mm) (β = −1.07, p =.007), and lower odds of having two or more periodontal pockets of ≥6 mm (OR = 0.80, 95% CI: 0.65 to 0.98) in fully adjusted models. Conclusions: CMPF, a validated biomarker of fatty fish consumption, is associated with less periodontal inflammation and periodontitis. Residual confounding cannot be ruled out, and future studies are warranted.",

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author = "Filip Ottosson and Lina Hultgren and Celine Fernandez and Gunnar Engstr{\"o}m and Marju Orho-Melander and Cecilia Kennb{\"a}ck and Margaretha Persson and Demmer, {Ryan T.} and Olle Melander and Bj{\"o}rn Klinge and Nilsson, {Peter M.} and Daniel J{\"o}nsson",

note = "Funding Information: Malm{\"o} Offspring Dental Study (MODS) was supported by grants from Oral Health Related Research by Region Sk{\aa}ne, the Crafoord Foundation, the Albert P{\aa}hlsson Foundation, and the Public Dental Service of Sk{\aa}ne. Malm{\"o} Offspring Study (MOS) was supported by the Research Council of Sweden, the Heart and Lung Foundation, and the Region Sk{\aa}ne County Council (ALF) grant. The authors would like to extend their gratitude to the following people working within the MODS study: the dentists, who examined the participants, (Liselott Bennvid, Elisabeth Hansson, Demir Cirgic, and Elisabeth Larsson) and biomedical scientists and nurses (Johanna Karlsson, Anna Hallberg, Christina Neroth, Anders Holm, and Ingeg{\"a}rd Lundgren Svensson). We are also profoundly grateful to the MOS/MODS participants for their participation in this research. Funding Information: Malm{\"o} Offspring Dental Study (MODS) was supported by grants from Oral Health Related Research by Region Sk{\aa}ne, the Crafoord Foundation, the Albert P{\aa}hlsson Foundation, and the Public Dental Service of Sk{\aa}ne. Malm{\"o} Offspring Study (MOS) was supported by the Research Council of Sweden, the Heart and Lung Foundation, and the Region Sk{\aa}ne County Council (ALF) grant. The authors would like to extend their gratitude to the following people working within the MODS study: the dentists, who examined the participants, (Liselott Bennvid, Elisabeth Hansson, Demir Cirgic, and Elisabeth Larsson) and biomedical scientists and nurses (Johanna Karlsson, Anna Hallberg, Christina Neroth, Anders Holm, and Ingeg{\"a}rd Lundgren Svensson). We are also profoundly grateful to the MOS/MODS participants for their participation in this research. Publisher Copyright: {\textcopyright} 2022 The Authors. Journal of Clinical Periodontology published by John Wiley & Sons Ltd.",

year = "2022",

month = apr,

doi = "10.1111/jcpe.13602",

language = "English (US)",

volume = "49",

pages = "353--361",

journal = "Journal of Clinical Periodontology",

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TY - JOUR

T1 - The inverse association between a fish consumption biomarker and gingival inflammation and periodontitis

T2 - A population-based study

AU - Ottosson, Filip

AU - Hultgren, Lina

AU - Fernandez, Celine

AU - Engström, Gunnar

AU - Orho-Melander, Marju

AU - Kennbäck, Cecilia

AU - Persson, Margaretha

AU - Demmer, Ryan T.

AU - Melander, Olle

AU - Klinge, Björn

AU - Nilsson, Peter M.

AU - Jönsson, Daniel

N1 - Funding Information: Malmö Offspring Dental Study (MODS) was supported by grants from Oral Health Related Research by Region Skåne, the Crafoord Foundation, the Albert Påhlsson Foundation, and the Public Dental Service of Skåne. Malmö Offspring Study (MOS) was supported by the Research Council of Sweden, the Heart and Lung Foundation, and the Region Skåne County Council (ALF) grant. The authors would like to extend their gratitude to the following people working within the MODS study: the dentists, who examined the participants, (Liselott Bennvid, Elisabeth Hansson, Demir Cirgic, and Elisabeth Larsson) and biomedical scientists and nurses (Johanna Karlsson, Anna Hallberg, Christina Neroth, Anders Holm, and Ingegärd Lundgren Svensson). We are also profoundly grateful to the MOS/MODS participants for their participation in this research. Funding Information: Malmö Offspring Dental Study (MODS) was supported by grants from Oral Health Related Research by Region Skåne, the Crafoord Foundation, the Albert Påhlsson Foundation, and the Public Dental Service of Skåne. Malmö Offspring Study (MOS) was supported by the Research Council of Sweden, the Heart and Lung Foundation, and the Region Skåne County Council (ALF) grant. The authors would like to extend their gratitude to the following people working within the MODS study: the dentists, who examined the participants, (Liselott Bennvid, Elisabeth Hansson, Demir Cirgic, and Elisabeth Larsson) and biomedical scientists and nurses (Johanna Karlsson, Anna Hallberg, Christina Neroth, Anders Holm, and Ingegärd Lundgren Svensson). We are also profoundly grateful to the MOS/MODS participants for their participation in this research. Publisher Copyright: © 2022 The Authors. Journal of Clinical Periodontology published by John Wiley & Sons Ltd.

PY - 2022/4

Y1 - 2022/4

N2 - Aim: The metabolite 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid (CMPF) is a fatty fish–intake biomarker. We investigated the association between plasma levels of CMPF in relation to gingival inflammation and periodontitis case definition, as well as the extent and severity variables. Materials and Methods: The Malmö Offspring Study is a population-based study, and the Malmö Offspring Dental Study (MODS) is its dental arm, including periodontal charting. Plasma CMPF was measured using liquid chromatography–mass spectrometry and studied in relation to periodontal diagnosis and parameters using multivariable linear or logistic regression modelling adjusting for age, sex, education, body mass index, fasting glucose, and smoking. Results: Metabolite data were available for 922 MODS participants. Higher CMPF levels were associated with less gingival inflammation (β = −2.12, p =.002) and lower odds of severe periodontitis (odds ratio [OR] = 0.74, 95% confidence interval [CI]: 0.56 to 0.98). Higher CMPF levels were also associated with more teeth (β = 0.19, p =.001), lower number of periodontal pockets (≥4 mm) (β = −1.07, p =.007), and lower odds of having two or more periodontal pockets of ≥6 mm (OR = 0.80, 95% CI: 0.65 to 0.98) in fully adjusted models. Conclusions: CMPF, a validated biomarker of fatty fish consumption, is associated with less periodontal inflammation and periodontitis. Residual confounding cannot be ruled out, and future studies are warranted.

AB - Aim: The metabolite 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid (CMPF) is a fatty fish–intake biomarker. We investigated the association between plasma levels of CMPF in relation to gingival inflammation and periodontitis case definition, as well as the extent and severity variables. Materials and Methods: The Malmö Offspring Study is a population-based study, and the Malmö Offspring Dental Study (MODS) is its dental arm, including periodontal charting. Plasma CMPF was measured using liquid chromatography–mass spectrometry and studied in relation to periodontal diagnosis and parameters using multivariable linear or logistic regression modelling adjusting for age, sex, education, body mass index, fasting glucose, and smoking. Results: Metabolite data were available for 922 MODS participants. Higher CMPF levels were associated with less gingival inflammation (β = −2.12, p =.002) and lower odds of severe periodontitis (odds ratio [OR] = 0.74, 95% confidence interval [CI]: 0.56 to 0.98). Higher CMPF levels were also associated with more teeth (β = 0.19, p =.001), lower number of periodontal pockets (≥4 mm) (β = −1.07, p =.007), and lower odds of having two or more periodontal pockets of ≥6 mm (OR = 0.80, 95% CI: 0.65 to 0.98) in fully adjusted models. Conclusions: CMPF, a validated biomarker of fatty fish consumption, is associated with less periodontal inflammation and periodontitis. Residual confounding cannot be ruled out, and future studies are warranted.

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KW - fish diet

KW - gingival inflammation

KW - metabolomics

KW - periodontitis

KW - Humans

KW - Periodontitis/diagnosis

KW - Inflammation

KW - Periodontal Pocket

KW - Gingivitis

KW - Multiple Organ Failure

KW - Animals

KW - Biomarkers

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DO - 10.1111/jcpe.13602

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SN - 0303-6979

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JO - Journal of Clinical Periodontology

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ER -

The inverse association between a fish consumption biomarker and gingival inflammation and periodontitis: A population-based study

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