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The intestinal absorption of a prodrug of the mGlu2/3 receptor agonist LY354740 is mediated by PEPT1: In situ rat intestinal perfusion studies
André H. Eriksson
, Manthena V.S. Varma
, Everett J. Perkins
, Cheryl L. Zimmerman
Pharmaceutics
Research output
:
Contribution to journal
›
Article
›
peer-review
23
Scopus citations
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Dive into the research topics of 'The intestinal absorption of a prodrug of the mGlu2/3 receptor agonist LY354740 is mediated by PEPT1: In situ rat intestinal perfusion studies'. Together they form a unique fingerprint.
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Keyphrases
In Situ
100%
Prodrug
100%
Intestinal Perfusion
100%
Intestinal Absorption
100%
MGlu2/3 Receptor Agonist
100%
Perfusion Study
100%
LY354740
100%
Peptide Transporter 1 (PepT1)
100%
Oral Bioavailability
22%
Single-pass Intestinal Perfusion
22%
High Concentration
11%
High Affinity
11%
Parameter Estimation
11%
Metabolic Activation
11%
Saturable
11%
Intracellular Accumulation
11%
Intestinal Peptides
11%
Michaelis-Menten
11%
MGlu2
11%
Linear Process
11%
Jmax
11%
In Vivo Absorption
11%
Gly-Sar
11%
Biochemistry, Genetics and Molecular Biology
Receptor Agonists
100%
Intestine Absorption
100%
Intestine Perfusion
100%
Eglumegad
100%
Animal Models
11%
Absorption
11%
Agonist
11%
Metabolic Activation
11%
Maximum Flux
11%
Pharmacology, Toxicology and Pharmaceutical Science
Prodrug
100%
Receptor Agonist
100%
Eglumegad
100%
Talaglumetad
100%
Bioavailability
22%