The intersection of purine and mitochondrial metabolism in cancer

Humberto De Vitto; Danushka B. Arachchige; Brian C. Richardson; Jarrod B. French

doi:10.3390/cells10102603

The intersection of purine and mitochondrial metabolism in cancer

Humberto De Vitto, Danushka B. Arachchige, Brian C. Richardson, Jarrod B. French

Research output: Contribution to journal › Review article › peer-review

37 Scopus citations

Abstract

Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of intermediates necessary for biosynthesis of macromolecules such as purines and pyrimidines. In this review, we highlight the role of purine and mitochondrial metabolism in cancer and how their intersection influences cancer progression, especially in ovarian cancer. Additionally, we address the importance of metabolic rewiring in cancer and how the evolving landscape of purine synthesis and mitochondria inhibitors can be potentially exploited for cancer treatment.

Original language	English (US)
Article number	2603
Journal	Cells
Volume	10
Issue number	10
DOIs	https://doi.org/10.3390/cells10102603
State	Published - Sep 30 2021

Bibliographical note

Funding Information:
Work on nucleotide metabolism in the French lab is supported by the National Institutes of Health (JBF, R35GM124898) and by the Hormel Institute through a Paint the Town Pink Award. DA would like to acknowledge the Fifth District Eagles for support in the form of an Eagles Telethon Postdoctoral Fellowship.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Amino acids
Cancers
Metabolic reprogramming
Mitochondrial metabolism
Purines

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cells10102603

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title = "The intersection of purine and mitochondrial metabolism in cancer",

abstract = "Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of intermediates necessary for biosynthesis of macromolecules such as purines and pyrimidines. In this review, we highlight the role of purine and mitochondrial metabolism in cancer and how their intersection influences cancer progression, especially in ovarian cancer. Additionally, we address the importance of metabolic rewiring in cancer and how the evolving landscape of purine synthesis and mitochondria inhibitors can be potentially exploited for cancer treatment.",

keywords = "Amino acids, Cancers, Metabolic reprogramming, Mitochondrial metabolism, Purines",

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note = "Funding Information: Work on nucleotide metabolism in the French lab is supported by the National Institutes of Health (JBF, R35GM124898) and by the Hormel Institute through a Paint the Town Pink Award. DA would like to acknowledge the Fifth District Eagles for support in the form of an Eagles Telethon Postdoctoral Fellowship. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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AU - Arachchige, Danushka B.

AU - Richardson, Brian C.

AU - French, Jarrod B.

N1 - Funding Information: Work on nucleotide metabolism in the French lab is supported by the National Institutes of Health (JBF, R35GM124898) and by the Hormel Institute through a Paint the Town Pink Award. DA would like to acknowledge the Fifth District Eagles for support in the form of an Eagles Telethon Postdoctoral Fellowship. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/9/30

Y1 - 2021/9/30

N2 - Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of intermediates necessary for biosynthesis of macromolecules such as purines and pyrimidines. In this review, we highlight the role of purine and mitochondrial metabolism in cancer and how their intersection influences cancer progression, especially in ovarian cancer. Additionally, we address the importance of metabolic rewiring in cancer and how the evolving landscape of purine synthesis and mitochondria inhibitors can be potentially exploited for cancer treatment.

AB - Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of intermediates necessary for biosynthesis of macromolecules such as purines and pyrimidines. In this review, we highlight the role of purine and mitochondrial metabolism in cancer and how their intersection influences cancer progression, especially in ovarian cancer. Additionally, we address the importance of metabolic rewiring in cancer and how the evolving landscape of purine synthesis and mitochondria inhibitors can be potentially exploited for cancer treatment.

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KW - Cancers

KW - Metabolic reprogramming

KW - Mitochondrial metabolism

KW - Purines

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The intersection of purine and mitochondrial metabolism in cancer

Abstract

Bibliographical note

Keywords

UN SDGs

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